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Disease Markers
Volume 2017 (2017), Article ID 7850708, 6 pages
https://doi.org/10.1155/2017/7850708
Review Article

Association between the TACC3 rs798766 Polymorphism and Risk of Urinary Bladder Cancer: A Synthesis Based on Current Evidence

1Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China
2Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France
3Université Paris Sud, Université Paris-Saclay, CNRS, UMR 144, 91405 Orsay, France
4Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Correspondence should be addressed to Xiang-Yu Meng

Received 7 February 2017; Accepted 30 April 2017; Published 5 June 2017

Academic Editor: Paola Gazzaniga

Copyright © 2017 Xiang-Yu Meng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. Methods. EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. “rs798766” and “urinary bladder cancer” were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated. Meta-analysis was performed using extracted data. Subgroup analysis by ethnicity was also performed. Population attributable risk (PAR) was calculated. Results. We found a significant association between rs798766[T] and increased risk of bladder cancer, allelic[T] , . Subgroup analysis by ethnicity revealed similar results, allelic[T] , in Caucasian subjects and allelic[T] , in Asian subjects. PAR based on pooled allelic ORs and the frequency of the risk allele in control subjects was 4.63% in the overall population and 3.92% in Asians and 4.36% in Caucasians. Conclusion. rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.