Disease Markers / 2017 / Article / Tab 4

Research Article

Matrix Metalloproteinases Polymorphisms as Prognostic Biomarkers in Malignant Pleural Mesothelioma

Table 4

The influence of MMP9 haplotypes on time to progression and overall survival.

HaplotypeEstimated frequencyTTP HR (95% CI)OS HR (95% CI)

ACGT0.560ReferenceReference
GCGC0.2140.98 (0.74–1.29)0.8770.97 (0.73–1.30)0.853
GCAC0.1291.13 (0.81–1.58)0.4600.96 (0.68–1.37)0.830
ACGC0.0531.33 (0.81–2.18)0.2611.85 (1.12–3.05)0.016
AGGC0.0242.14 (1.03–4.44)0.0422.07 (1.02–4.22)0.045
AGAC0.0202.93 (1.30–6.60)0.0103.38 (1.33–8.54)0.010

The SNPs are ordered from the 5- to 3-end as follows: rs17576, rs2250889, rs17577, and rs20544.

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