Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation
Table 2
Differential cellular staining pattern of NILCO and targets in type I and type II EmCa tissues from African-American and Chinese women.
African-American
Chinese
Type I ()
Type II ()
p value
Type I ()
Type II ()
p value
% positive
% positive
% positive
% positive
Notch1
Nucleus
1
1
0.0806
4
10
0.0779
Cytoplasm
30
60
0.0001
74
93
0.0184
Notch2
Nucleus
1
3
0.0001
12
11
0.2259
Cytoplasm
85
90
0.0001
79
91
0.0121
Notch3
Nucleus
1
4
0.0001
5
0
0.0001
Cytoplasm
71
64
0.0001
46
56
0.0001
Notch4
Nucleus
5
20
0.0001
4
12
0.0522
Cytoplasm
24
74
0.0001
68
63
0.5882
JAG1
Nucleus
2
2
0.5501
1
14
0.0001
Cytoplasm
80
94
0.0001
72
63
0.3446
DLL4
Nucleus
1
6
0.0001
15
39
0.0001
Cytoplasm
81
84
0.0061
72
88
0.0454
Survivin
Nucleus
51
75
0.0001
42
58
0.0450
Cytoplasm
30
19
0.0001
82
84
0.8104
OB-R
Nucleus
0
2
0.0001
0
0
n/a
Cytoplasm
39
70
0.0001
30
64
0.0001
IL-1R tI
Nucleus
1
3
0.0001
1
1
0.6359
Cytoplasm
55
63
0.0001
75
90
0.0001
Hey2
Nucleus
1
1
0.6224
0
0
n/a
Cytoplasm
90
90
0.7111
100
100
0.6841
Nuclear and cytoplasmic staining for NILCO and targets are expressed as % of positive immunoreactivity in type I and type II EmCa from African-American and Chinese women. Notch1–4 (Notch receptor type 1 through 4); JAG1: Jagged1; DLL4: Delta-like ligand 4 (Notch ligands); Survivin, Hey2 (hairy and enhancer of split-related protein 2), IL-1R t1 (interleukin-1 receptor type 1), and OB-R (leptin receptor). The p value was calculated by two-sample t-test.
