Disease Markers / 2017 / Article / Tab 3

Review Article

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness

Table 3

Effect of vitamin E and C supplementation and arterial stiffness in human subjects.

AuthorsYear of publicationFollow-upDose of vitamin E and CStudy population Results

Vucinovic et al. [37] 20151 week600 IU vitamin E12 healthy malesHyperoxia resulted in increased augmentation index and lipid peroxides and decreased nitrite in placebo; not in the antioxidant group
1,000 mg vitamin C
600 mg alpha-lipoic acid

Hildreth et al.
[38]
2014Infusion of 7.5 g ascorbic acid97 healthy women (premenopausal, perimenopausal and postmenopausal)Improvement of arterial compliance in late perimenopausal and postmenopausal women

Ives et al.
[39]
2014 90 minutesOral antioxidant cocktail30 patients with chronic obstructive pulmonary diseaseVascular dysfunction mediated by an altered redox balance can be mitigated by an oral antioxidant; the antioxidant cocktail improved also PWV 
(1) Dose: 300 mg alpha lipoic acid, 500 mg vitamin C, 200 IU vitamin E
(2) Dose: the same doses of alpha lipoic acid and vitamin C, 400 IU vitamin E

Veringa et al.
[40]
201218 monthsPravastatin supplemented with vitamin E after 6 months and homocysteine lowering therapy after other 6 months93 chronic kidney disease patientsSignificant improvement of compliance and distensibility in the common carotid and femoral artery

Shargorodsky et al. [16]20106 months1,000 mg vitamin C, 400 IU vitamin E, 120 mg co-enzyme Q, 200 mcg selenium70 patients with multiple cardiovascular risk factors (at least 2)Significant increase of large and small vessel elasticity

Rasool et al.
[41]
20082 months50, 100 and 200 mg/day tocotrienol rich vitamin E36 healthy menImprovement of arterial compliance
after 100 and 200 mg/day tocotrienol rich vitamin E; NO effect on serum lipids

Kelly et al.
[42]
20088 hoursOral dose of 2 g vitamin C26 healthy human volunteersNo effect on augmentation index and markers of oxidative stress

Plantinga et al. [43] 20078 weeks400 IU vitamin E30 male with essential hypertensionBeneficial effects on endothelium-dependent vasodilation and arterial stiffness
1 g vitamin C

Katayama et al. [44]20042 hoursSingle dose 2 g vitamin C before smoking17 healthy male volunteersSignificant reduction of smoking-induced elevation of brachial-ankle PWV

Mullan et al.
[45]
2004120 minutes2 g i.v. ascorbic acid12 healthy menPretreatment with ascorbic acid prevented the hyperglycemia induced increase of the central aortic pulse pressure and blood pressure

Mullan et al. [46]20024 weeksOral 500 mg ascorbic acid/day30 patients with type 2 diabetes mellituslowered blood pressure, decreased arterial stiffness

Skyrme-Jones et al.
[47]
20003 months1,000 IU/day oral vitamin E41 young diabetic subjects (type 1 diabetes mellitus)Improvement of endothelial vasodilation; no effect on systemic arterial compliance

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