Research Article
Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
Table 4
Comparison of genotypes between children born from preeclamptic and noncomplicated pregnancies.
| | Fetal genotypes and alleles | PE group
N (%) | Control group
N (%) | | pHWE |
| | −1607 1G/2G MMP1 (rs1799750) | | | | | | 1G/1G | 30 (35%) | 12 (14%) | <0.01 | 0.503 | | 1G/2G | 43 (50%) | 36 (42%) | 0.316 | | 2G/2G | 13 (15%) | 37 (44%) | <0.001 | | 1G | 103 (60%) | 60 (35%) | <0.0001 | | | 2G | 69 (40%) | 110 (65%) | |
| | −1171 5A/6A MMP3 (rs35068180) | | | | | | 5A/5A | 12 (14%) | 17 (20%) | 0.291 | 0.841 | | 5A/6A | 62 (72%) | 41 (48%) | <0.01 | | 6A/6A | 12 (14%) | 27 (32%) | <0.01 | | 5A | 86 (50%) | 75 (44%) | 0.276 | | | 6A | 86 (50%) | 95 (56%) | |
| | −1562C/T MMP9 (rs3918242) | | | | | | CC | 67 (78%) | 61 (72%) | 0.354 | 0.487 | | CT | 19 (22%) | 21 (25%) | 0.687 | | TT | 0 (0%) | 3 (3%) | 0.240 | | C | 153 (89%) | 143 (84%) | 0.190 | | | T | 19 (11%) | 27 (16%) | |
| | −735 C/T MMP2 (rs2285053) | | | | | | CC | 66 (77%) | 69 (81%) | 0.477 | 0.857 | | CT | 18 (21%) | 15 (18%) | 0.586 | | TT | 2 (2%) | 1 (1%) | 0.992 | | C | 150 (87%) | 153 (90%) | 0.417 | | | T | 22 (13%) | 17 (10%) | |
| | −1306 C/T MMP2 (rs243865) | | | | | | CC | 50 (58%) | 48 (56%) | 0.825 | 0.304 | | CT | 27 (31%) | 34 (40%) | 0.240 | | TT | 9 (11%) | 3 (4%) | 0.140 | | C | 127 (74%) | 130 (76%) | 0.573 | | | T | 45 (26%) | 40 (24%) | |
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For value analysis, the chi 2 or Yates’ corrected chi 2 tests were used; HWE: Hardy–Weinberg equilibrium. |
