Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

Table 6

Distribution of genotypes of studied polymorphisms among female and male preeclamptic and control groups.

Genotypes	Female PE children	Female control; children		OR (95% CI)	Male PE children	Male control children		OR (95% CI)
−1607 1G/2G MMP1 (rs1799750)
1G/1G	12 (35%)	5 (10%)	<0.05	4.58 (1.43–14.67)	18 (35%)	7 (18%)	0.085	NS
1G/2G	15 (44%)	21 (45%)	0.959	NS	28 (54%)	15 (39%)	0.176	NS
2G/2G	7 (21%)	21 (45%)	<0.05	0.32 (0.12–0.88)	6 (12%)	16 (42%)	<0.01	0.18 (0.06–0.52)
−1171 5A/6A MMP3 (rs35068180)
5A/5A	4 (12%)	9 (19%)	0.557	NS	8 (15%)	8 (21%)	0.678	NS
5A/6A	25 (73%)	26 (55%)	0.091	NS	37 (71%)	15 (39%)	<0.01	3.78 (1.56–9.16)
6A/6A	5 (15%)	12 (26%)	0.366	NS	7 (13%)	15 (39%)	<0.01	0.24 (0.08–0.67)
−1562C/T MMP9 (rs3918242)
CC	29 (85%)	32 (68%)	0.131	NS	38 (73%)	29 (76%)	0.918	NS
CT	5 (15%)	14 (30%)	0.188	NS	14 (37%)	7 (18%)	0.490	NS
TT	0 (0%)	1 (2%)	0.870	NS	0 (0%)	2 (5%)	0.343	NS
−735 C/T MMP2 (rs2285053)
CC	25 (73%)	35 (74%)	0.872	NS	41 (79%)	34 (89%)	0.294	NS
CT	8 (24%)	11 (23%)	0.801	NS	10 (19%)	4 (11%)	0.406	NS
TT	1 (3%)	1 (2%)	0.622	NS	1 (2%)	0 (0%)	0.874	NS
−1306 C/T MMP2 (rs243865)
CC	25 (73%)	28 (60%)	0.189	NS	25 (48%)	20 (53%)	0.669	NS
CT	8 (24%)	19 (40%)	0.107	NS	19 (37%)	15 (39%)	0.777	NS
TT	1 (3%)	0 (0%)	0.870	NS	8 (15%)	3 (8%)	0.436	NS

For value analysis, the chi² or Yates’ corrected chi² tests were used; NS: not significant.