Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

Table 7

Haplotype association with the predisposition to preeclampsia.

	Haplotype association with preeclampsia occurrence
	MMP1 rs1799750	MMP3 rs35068180	MMP9 rs3918242	MMP2 rs2285053	MMP2 rs243865	OR (95% Cl)	value
Maternal haplotype set
(1)	2G	6A	C	C	C	1	—
(2)	1G	5A	C	C	C	0.78 (0.29–2.12)	0.63
(3)	2G	5A	C	C	C	2.90 (0.92–9.17)	0.072
(4)	1G	6A	C	C	C	2.64 (0.77–9.02)	0.12
(5)	2G	6A	C	C	T	0.63 (0.18–2.21)	0.47
(6)	2G	6A	C	C	C	1.66 (0.47–5.83)	0.43
Fetal haplotype set
(1)	2G	6A	C	C	C	1	—
(2)	1G	5A	C	C	C	0.88 (0.28–2.75)	0.82
(3)	2G	5A	C	C	C	0.36 (0.09–1.48)	0.16
(4)	1G	6A	C	C	C	0.99 (0.28–3.44)	0.98
(5)	2G	6A	C	C	T	0.37 (0.08–1.77)	0.21
(6)	1G	6A	C	C	T	2.59 (0.61–11.09)	0.2
(7)	1G	5A	C	T	C	2.34 (0.59–9.29)	0.23
(8)	1G	5A	C	C	T	5.93 (1.06–33.19)	<0.05
(9)	2G	5A	T	C	C	0.98 (0.16–5.93)	0.98

OR: odds ratio; CI: confidence interval; result is statistically significant for value < 0.05.