Adipose Tissue-Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea-Predominant IBS

Table 2

Correlation between GSRS combination score and analytical measurements in all subjects (51 subjects; HC, D-IBS (−), and D-IBS (+) patients).

	Abdominal pain cluster [r (p)]	Indigestion cluster [r (p)]	Diarrhoea cluster [r (p)]
IL6	0.134 (0.347)	0.118 (0.409)	0.183 (0.198)
IL8	0.442 (0.00126)	0.361 (0.00941)	0.428 (0.00182)
TNF-alfa	0.434 (0.00157)	0.354 (0.0110)	0.421 (0.00224)
LPS	0.0259 (0.856)	0.178 (0.211)	0.096 (0.517)
TLR-4	−0.0801 (0.575)	−0.0586 (0.682)	0.0978 (0.493)
Leptin	0.210 (0.139)	0.452 (0.000943)	0.0828 (0.562)
Adiponectin	0.428 (0.00187)	0.293 (0.0368)	0.303 (0.0309)
BDNF	0.353 (0.0113)	0.404 (0.00348)	0.0668 (0.640)
NT	−0.0787 (0.581)	−0.159 (0.263)	−0.188 (0.184)

HC: healthy controls; D-IBS (+)/(−): diarrhoea-predominant IBS according to presence/absence of impaired permeability. Analysis was performed by the Spearman correlation coefficient. The correlations that satisfied the Bonferroni correction (9 variables 0.05/9 = 0.005) are highlighted in bold.