Research Article

Vitamin D and Incidence of Prediabetes or Type 2 Diabetes: A Four-Year Follow-Up Community-Based Study

Table 1

Characteristics at entry according to quartiles of baseline 25(OH)D level in subjects who were initially normoglycemic.

Q1Q2Q3Q4P

Range of 25(OH)D (nmol/L)13.93–33.5633.57–40.1140.12–46.3846.39–80.30
n122123123122
Percent women n (%)88 (72.1)79 (64.2)80 (65.0)63 (51.6)0.010
Age (years)44.8 ± 12.845.2 ± 13.845.6 ± 13.547.8 ± 13.80.311
Current smoking n (%)20 (16.4)28 (22.8)20 (16.3)25 (20.5)0.485
Drinking n (%)28 (23.0)38 (30.9)22 (17.9)36 (29.5)0.068
Leisure-time physical activity n (%)98 (80.3)115 (93.5)98 (79.7)96 (78.7)0.005
Family history of diabetes n (%)21 (17.2)16 (13.0)12 (9.8)17 (13.9)0.397
BMI (kg/m2)23.1 ± 3.222.8 ± 3.023.5 ± 3.223.2 ± 3.10.380
WHR0.85 ± 0.110.86 ± 0.080.86 ± 0.080.86 ± 0.080.711
SBP (mmHg)120.4 ± 18.4118.5 ± 19.99115.1 ± 14.6118.2 ± 17.90.145
DBP (mmHg)76.8 ± 10.275.9 ± 10.474.1 ± 8.776.2 ± 10.10.165
FPG (mmol/L)4.55 ± 0.564.62 ± 0.534.63 ± 0.494.63 ± 0.680.268
0.5 h PG (mmol/L)7.51 ± 1.447.74 ± 1.767.49 ± 1.667.89 ± 1.690.158
2 h PG (mmol/L)5.38 ± 1.165.52 ± 1.115.45 ± 1.135.44 ± 1.020.843
TG (mmol/L)1.23 (0.91, 1.68)1.12 (0.89, 1.58)1.17 (0.90, 1.67)1.12 (0.89, 1.76)0.842
TC (mmol/L)5.14 ± 0.964.95 ± 0.994.95 ± 0.884.92 ± 1.030.255
LDL-C (mmol/L)3.04 ± 0.842.89 ± 0.792.95 ± 0.813.00 ± 0.920.515
HDL-C (mmol/L)1.50 ± 0.351.47 ± 0.361.41 ± 0.321.36 ± 0.340.005
Fasting insulin (μU/mL)7.04 (5.67, 8.65)6.79 (5.37, 8.79)6.65 (5.31, 8.60)6.71 (5.44, 8.68)0.425
0.5 h insulin (μU/mL)34.22 (19.45, 50.41)29.74 (19.31, 44.19)30.66 (18.40, 53.34)34.70 (20.53, 57.95)0.720
2 h insulin (μU/mL)25.89 (17.05, 40.32)27.26 (18.45, 41.98)23.88 (16.34, 42.92)24.02 (16.27, 38.52)0.672
HOMA-IR1.63 ± 1.061.53 ± 0.691.48 ± 0.551.51 ± 0.610.471
ISIcomp8.90 ± 3.469.39 ± 4.309.20 ± 3.319.06 ± 3.640.862
ΔI30/ΔG309.17 (4.67, 14.68)7.38 (4.36, 16.83)8.81 (4.10, 16.43)9.54 (4.34, 17.90)0.889
(ΔI30/ΔG30)/HOMA-IR6.04 (3.20, 11.14)5.68 (3.02, 12.32)6.49 (3.0, 13.90)6.88 (3.37, 11.76)0.835

Data is expressed as mean ± standard deviation, median (interquartile range), or percentage. 25(OH)D: 25-hydroxyvitamin D; Q: quartile; BMI: body mass index; WHR: waist/hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; TG: triglyceride; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; HOMA-IR: homeostasis model of assessment for insulin resistance index; ISIcomp: insulin sensitive index composite; ΔI30/ΔG30: the ratio of the incremental insulin to glucose responses over the first 30 min during the OGTT.