Identifying the Best Marker Combination in CEA, CA125, CY211, NSE, and SCC for Lung Cancer Screening by Combining ROC Curve and Logistic Regression Analyses: Is It Feasible?

Table 4

Values of various marker combinations for lung cancer screening in patients with pneumonia.

	SEN	SPE	PPV	NPV	+LR	−LR	Yden	AUC
CEA + CA125	0.656	0.592	0.610	0.638	1.608	0.581	0.248	0.669
CEA + CY211^▲	0.712	0.585	0.626	0.676	1.715	0.492	0.297	0.713
CEA + NSE	0.632	0.657	0.642	0.647	1.842	0.560	0.289	0.698
CA125 + CY211	0.765	0.434	0.568	0.654	1.351	0.543	0.198	0.660
CA125 + NSE	0.692	0.478	0.564	0.615	1.327	0.644	0.170	0.654
CY211 + NSE	0.744	0.477	0.581	0.657	1.422	0.537	0.221	0.676
CEA + CA125 + CY211	0.796	0.417	0.571	0.678	1.366	0.489	0.213	0.693
CEA + CA125 + NSE	0.747	0.443	0.566	0.643	1.342	0.570	0.190	0.689
CA125 + CY211 + NSE	0.829	0.332	0.547	0.667	1.242	0.513	0.162	0.673
CEA + CY211 + NSE^★	0.796	0.460	0.589	0.699	1.474	0.443	0.256	0.715
CEA + CA125 + CY211 + NSE	0.852	0.325	0.551	0.692	1.261	0.457	0.176	0.701