Association between a Single Nucleotide Polymorphism in the 3-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population

Table 3

Association between the ARHGEF18 rs3745357 polymorphism and risk of pulmonary hypertension without history of coronary heart disease.

Genetic model	Genotype	Patients^a	Control	Logistic regression		Logistic regression (adjusted)^c
				OR (95% CI)	value	OR^c (95% CI)	value
Codominant	TT	8 (17)	57 (32.4)	1.00		1.00
	CT	18 (38.3)	81 (46)	1.58 (0.64–3.89)	0.0053	1.65 (0.38–7.17)	0.13
	CC	21 (44.7)	38 (21.6)	3.94 (1.58–9.80)		4.10 (0.90–18.68)
Dominant	TT	21 (44.7)	57 (21.5)	1		1.00
	CT/CC	26 (55.3)	119 (78.5)	2.34 (1.02–5.32)	0.032	2.48 (0.64–9.60)	0.18
Recessive	TT/CT	39 (83)	138 (70.2)	1.00		1.00
	CC	8 (17)	38 (29.8)	2.93 (1.49–5.78)	0.0021	2.90 (0.97–8.73)	0.055
Overdominant	TT/CC	29 (61.7)	62 (51.2)	1.00		1.00
	CT	18 (38.3)	59 (48.8)	0.73 (0.38–1.41)	0.34	0.67 (0.23–1.94)	0.46

^aPH patients without history of coronary heart disease; ^cadjusted by sex and age.