Association between a Single Nucleotide Polymorphism in the 3-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population

Table 4

Association between the ARHGEF18 rs3745357 polymorphism and risk of pulmonary hypertension with history of coronary heart disease.

Genetic model	Genotype	Patients^b	Control	Logistic regression		Logistic regression (adjusted)^c
				OR (95% CI)	value	OR^c (95% CI)	value
Codominant	TT	37 (52.9)	57 (32.4)	1.00		1.00
	CT	20 (28.6)	81 (46)	0.38 (0.20–0.72)	0.0092	0.14 (0.02–1.02)	0.011
	CC	13 (18.6)	38 (21.6)	0.53 (0.25–1.12)		0.03 (0.00–0.46)
Dominant	TT	37 (52.9)	57 (32.4)	1		1.00
	CT/CC	33 (47.1)	119 (67.6)	0.43 (0.24–0.75)	0.0031	0.10 (0.02–0.69)	0.009
Recessive	TT/CT	57 (81.4)	138 (78.4)	1.00		1.00
	CC	13 (18.6)	38 (21.6)	0.83 (0.41–1.67)	0.6	0.11 (0.01–0.93)	0.031
Overdominant	TT/CC	50 (71.4)	95 (54)	1.00		1.00
	CT	20 (28.6)	81 (46)	0.47 (0.26–0.85)	0.011	0.54 (0.12–2.44)	0.42

^bPH patients with history of coronary heart disease; ^cadjusted by sex and age.