Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients

Table 1

Amino acid substitutions in HCV NS5A protein from DAA treatment-naïve patients.

Subtype	Isolate	RAS	RAP	Resistance to DAA	Reference
1a	003		H58P	—	HARVONI prescription
1a	020		K24Q	—	[5, 49]
1a	032		H58P	—	HARVONI Prescription
1b	016	L31 V		DCV, LDV, EBV	[5, 6]
1b	039	L31 M		DCV, LDV, EBV	[5, 47, 48]

Daclatasvir (DCV), ledipasvir (LDV), elbasvir (EBV). Harvoni prescription, https://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf.