Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies

Table 1

Characteristics of the included studies on association of IL-10-592 (-590, -597) C>A gene polymorphisms with periodontitis.

Author (year)	Population	Study type	Cases/controls	Smoking status	Control type	Gender	Quality (NOS)	Locus of SNPs
Scarel-Caminaga et al. (2004) [16]	Brazilian Caucasian	Case-control	48/36	No smoke	HC	Matched	7/9	-592
Sumer et al. (2007) [17]	Turkish Caucasian	Case-control	75/73	No smoke	CC	Matched	8/9	-597
Claudino et al. (2008) [18]	Brazilian (mixed)	Case-control	116/173	No smoke	CC	Not Matched	6/9	-592
Reichert et al. (2008) [19]	German Caucasian	Case-control	59/34	Mixed	CC	Matched	6/9	-590
Hu et al. (2009) [20]	Taiwanese Han	Case-control	210/126	Mixed	HC	Matched	5/9	-592
Li et al. (2009) [21]	Chinese Han	Case-control	30/30	Unknown	HC	Matched	6/9	-592
Atanasovska-Stojanovska et al. (2012) [22]	Macedonian Caucasian	Case-control	111/299	No smoke	HC	Matched	7/9	-592
Garlet et al. (2012) [23]	Brazilian (mixed)	Case-control	197/214	No smoke	HC	Matched	7/9	-592
Jaradat et al. (2012) [24]	Jordanian	Case-control	190/86	No smoke	CC	Matched	7/9	-597
Scapoli et al. (2012) [25]	Italian Caucasian	Case-control	182/230	Mixed	Unknown	Unknown	5/9	-592
Scapoli et al. (2015) [26]	Italian Caucasian	Case-control	182/230	No smoke	Unknown	Matched	6/9	-592
Silveira et al. (2016) [27]	Brazilian	Case-control	111/61	No smoke	HC	Matched	6/9	-592
Gorgun et al. (2017) [29]	Turkish	Case-control	53/50	No smoke	HC	Matched	7/9	-597
Lopes et al. (2017) [28]	Brazilian	Case-control	55/150	Unknown	HC	Matched	4/9	-592
Toker et al. (2017) [30]	Turkish Caucasian	Case-control	103/38	No smoke	HC	Matched	6/9	-597
Zhang et al. (2017) [31]	Chinese Uygur	Case-control	200/100	Unknown	CC	Matched	7/9	-597
Moudi et al. (2018) [32]	Iranian	Case-control	210/100	No smoke	HC	Matched	7/9	-592
Toker et al. (2018) [33]	Turkish	Case-control	52/50	No smoke	HC	Matched	7/9	-592

HC/CC: hospital/community control; NOS: Newcastle-Ottawa scale; SNPs: single-nucleotide polymorphisms.