Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies

Table 2

Distribution of IL-10-592 (-590, -597) C>A genotypes and allele frequency among periodontitis patients and control subjects.

First author	Year	Cases (CP/AgP)	Controls	Genotype distribution						Allele distribution				for HWE (control)
				Cases			Controls			Cases		Controls
				CC	AC	AA	CC	AC	AA	C	A	C	A
Scarel-Caminaga [16]	2004	48 (CP)	36	12	34	2	19	14	3	58	38	52	20	0.85
Sumer [17]	2007	75 (CP)	73	24	40	11	43	29	1	88	62	115	31	0.11
Claudino [18]	2008	116 (CP)	173	33	65	18	84	69	20	131	101	237	109	0.32
Reichert [19]	2008	27 (CP)	34	20	7	0	23	10	1	47	7	56	12	0.94
		32 (AgP)		18	8	6				44	20
Hu [20]	2009	145 (CP)	126	27	32	86	16	48	62	86	204	80	172	0.17
		65 (AgP)		6	21	38				33	97
Li [21]	2009	30 (AgP)	30	7	11	12	5	12	13	25	35	22	38	0.275
Atanasovska-Stojanovska [22]	2012	111 (CP)	299	62	45	4	154	117	28	169	53	425	173	0.40
Scapoli [25]	2012	178 (CP)	222	75	83	20	115	91	16	233	123	321	123	0.73
Garlet [23]	2012	197 (CP)	214	57	107	33	106	80	28	221	173	292	136	0.04
Jaradat [24]	2012	105 (CP)	86	60	32	13	63	19	4	152	58	145	27	0.13
Scapoli [26]	2015	279 (CP)	213	143	109	27	114	83	16	395	163	311	115	0.87
Silveira [27]	2016	61 (CP)	61	22	32	7	27	26	8	76	46	80	42	0.66
		50 (AgP)		20	21	9				61	39
Gorgun [29]	2017	53 (AgP)	50	7	34	12	3	45	2	48	58	51	49	<0.001
Lopes [28]	2017	55 (CP)	150	0	42	13	48	83	19	42	68	179	121	0.07
Toker [30]	2017	45 (CP)	38	5	24	16	2	34	2	34	56	38	38	<0.001
		50 (AgP)		6	38	14				50	66
Zhang [31]	2017	199 (CP)	100	54	95	50	29	52	19	203	195	110	90	0.96
Moudi [32]	2018	210 (CP)	100	12	152	46	10	61	29	176	214	81	119	0.008
Toker [33]	2018	52 (CP)	50	7	27	18	3	45	2	41	63	61	49	<0.001

CP/AgP: chronic/aggressive periodontitis; HWE: Hardy–Weinberg equilibrium fulfillment.