Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies
Table 3
IL-10-592 (-590, -597) C>A polymorphism and periodontitis.
Genetic model
Total/subgroup
Number of studies
Cases/controls
OR ( value)
95% CI
2, % ( valuea)
Egger ( value)
Model of meta-analysis
IL-10-592 (-590, -597) C>A polymorphism and chronic periodontitis
A versus C
Total
16
1903/1975
1.38 (<0.001)
1.17–1.64
62.1 (0.001)
0.071
Random
Total for HWEb
12
1418/1580
1.38 (0.002)
1.12–1.70
65.9 (<0.001)
0.017
Random
Caucasian
7
763/915
1.31 (0.088)
0.96–1.77
68.4 (0.004)
0.047
Random
Nonsmoker
11
1299/1343
1.43 (0.002)
1.15–1.79
68.0 (<0.001)
0.294
Random
AA versus CC+CA
Total
16
1903/1975
1.49 (0.02)
1.06–2.10
59.4 (0.001)
0.243
Random
Total for HWE
12
1399/1573
1.42 (0.002)
1.13–1.78
31.0 (0.14)
0.234
Fixed
Caucasian
7
763/915
1.50 (0.33)
0.66–3.43
68.0 (0.005)
0.647
Random
Nonsmoker
11
1299/1343
1.56 (0.10)
0.91–2.66
71.0 (<0.001)
0.993
Random
CC versus AA+CA
Total
16
1903/1975
0.69 (0.01)
0.51–0.92
68.0 (<0.001)
0.208
Random
Total for HWE
12
1399/1573
0.68 (0.02)
0.49–0.93
69.0 (<0.001)
0.149
Random
Caucasian
7
763/915
0.74 (0.15)
0.50–1.11
66.2 (0.007)
0.676
Random
Nonsmoker
11
1299/1343
0.62 (0.006)
0.44–0.87
68.0 (<0.001)
0.450
Random
IL-10-592 (-590, -597) C>A polymorphism and aggressive periodontitis
A versus C
Total
6
288/399
1.29 (0.04)
1.01–1.63
0.0 (0.69)
0.28
Fixed
Caucasian
2
90/72
1.55 (0.07)
0.97–2.48
0.0 (0.35)
—
Fixed
Nonsmoker
3
161/149
1.26 (0.157)
0.92–1.74
0.0 (0.98)
—
Fixed
AA versus CC+CA
Total
6
288/399
1.93 (0.001)
1.30–2.89
47.5 (0.09)
—
Fixed
Caucasian
2
90/72
6.29 (0.004)
1.78–22.21
0.0 (0.83)
—
Fixed
Nonsmoker
3
161/149
3.24 (0.001)
1.59–6.61
47.0 (0.15)
—
Fixed
CC versus AA+CA
Total
6
288/399
0.98 (0.91)
0.64–1.49
0.0 (0.52)
0.43
Fixed
Caucasian
2
90/72
0.88 (0.76)
0.39–2.01
34.0 (0.22)
—
Fixed
Nonsmoker
3
161/149
1.19 (0.58)
0.65–2.17
5.6 (0.35)
—
Fixed
OR: odds ratio; CI: confidence interval. a value for heterogeneity. bHardy–Weinberg equilibrium fulfillment.
