Disease Markers

Review Article

Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Table 3

False-positive report probability values for associations between cancer risk and MnSOD Val16Ala polymorphism.


Genotype	Crude OR (95% CI)	value^a	Statistical power^b	Prior probability
Genotype	Crude OR (95% CI)	value^a	Statistical power^b	0.25	0.1	0.01	0.001	0.0001

All
Homozygous	1.09 (1.00–1.19)	0.054	1.000	0.140	0.328	0.843	0.982	0.998
Heterozygous	1.07 (1.02–1.12)	0.004	1.000	0.011	0.032	0.267	0.787	0.974
Dominant	1.08 (1.02–1.14)	0.005	1.000	0.016	0.045	0.343	0.840	0.981
Allele comparison	1.06 (1.02–1.11)	0.013	1.000	0.038	0.106	0.567	0.930	0.992
Cancer type—prostate cancer
Heterozygous	1.14 (1.05–1.24)	0.002	1.000	0.007	0.020	0.183	0.693	0.958
Dominant	1.14 (1.05–1.23)	0.001	1.000	0.002	0.006	0.067	0.420	0.879
Allele comparison	1.07 (1.00–1.15)	0.066	1.000	0.165	0.372	0.867	0.985	0.998
Ethnicity—Asian
Homozygous	1.82 (1.15–2.88)	0.011	0.204	0.134	0.317	0.836	0.981	0.998
Recessive	1.76 (1.16–2.68)	0.008	0.228	0.100	0.249	0.785	0.974	0.997
Ethnicity–Caucasian
Heterozygous	1.08 (1.03–1.13)	0.001	1.000	0.003	0.008	0.078	0.462	0.896
Dominant	1.08 (1.02–1.14)	0.005	1.000	0.016	0.045	0.343	0.840	0.981
Allele comparison	1.04 (1.00–1.09)	0.102	1.000	0.234	0.478	0.910	0.990	0.999
Control source—PB
Homozygous	1.10 (1.01–1.19)	0.018	1.000	0.050	0.136	0.634	0.946	0.994
Heterozygous	1.07 (1.02–1.12)	0.004	1.000	0.011	0.032	0.267	0.787	0.974
Dominant	1.07 (1.02–1.13)	0.015	1.000	0.043	0.119	0.599	0.938	0.993
Allele comparison	1.04 (1.00–1.08)	0.042	1.000	0.111	0.273	0.805	0.977	0.998
Control source—HB
Recessive	1.16 (1.01–1.34)	0.044	1.000	0.116	0.282	0.812	0.978	0.998
Allele comparison	1.13 (1.03–1.24)	0.010	1.000	0.029	0.082	0.495	0.908	0.990
Quality score—low
Allele comparison	1.12 (1.02–1.23)	0.018	1.000	0.051	0.138	0.637	0.947	0.994
Quality score—high
Homozygous	1.08 (1.00–1.17)	0.059	1.000	0.151	0.349	0.855	0.983	0.998
Heterozygous	1.07 (1.02–1.13)	0.015	1.000	0.043	0.119	0.599	0.938	0.993
Dominant	1.07 (1.02–1.14)	0.036	1.000	0.098	0.247	0.783	0.973	0.997
Allele comparison	1.04 (1.00–1.09)	0.102	1.000	0.234	0.478	0.910	0.990	0.999

^aChi-square test was used to calculate the genotype frequency distributions; ^bstatistical power was calculated using the number of observations in the subgroup and the OR and values in this table.