Haplotypes of TNFα/β Genes Associated with Sex-Specific Paranoid Schizophrenic Risk in Tunisian Population
Table 1
Distribution of genotype and allele frequencies of rs909253, rs1799724, and rs361525 in control subjects and patients with schizophrenia.
Controls ()
Patients ()
value
OR (95% CI)
Controls
Patients
value
OR (95% CI)
Controls
Patients
value
OR (95% CI)
Males ()
Males ()
Females ()
Females ()
rs909253
AA
111 (53.4)
84 (40.4)
1
85 (53.4)
67 (38.9)
1
26 (53.1)
17 (47.2)
1
AG
79 (38)
93 (44.7)
0.03
1.55 (1.02–2.35)
61 (38.4)
77 (44.8)
0.04
1.59 (1.005–2.55)
18 (36.7)
16 (44.5)
0.5
1.35 (0.53–3.41)
GG
18 (8.6)
31 (14.9)
0.01
2.26 (1.19–4.40)
13 (8.2)
28 (16.3)
0.006
2.71 (1.31–5.80)
5 (10.2)
3 (8.3)
0.9
0.91 (0.16–4.51)
Allele
A
301 (72.4)
261 (62.7)
1
231 (72.6)
211 (61.3)
1
70 (71.4)
50 (69.4)
1
G
115 (27.6)
155 (37.3)
0.003
1.55 (1.16–2.08)
87 (27.4)
133 (38.7)
0.002
1.67 (1.20–2.32)
28 (28.6)
22 (30.6)
0.7
1.09 (0.55–2.14)
rs1799724
CC
170 (81.7)
147 (70.7)
1
133 (83.7)
124 (72.1)
1
37 (75.5)
23 (63.9)
1
CT
35 (16.8)
54 (26)
0.01
1.78 (1.1–2.89)
25 (15.7)
42 (24.4)
0.03
1.79 (1.03–3.15)
10 (20.4)
12 (33.3)
0.2
1.91 (0.7–5.29)
TT
3 (1.5)
7 (3.3)
0.1
2.69 (0.69–13.01)
1 (0.6)
6 (3.5)
0.06
6.39 (0.92–150.1)
2 (4.1)
1 (2.8)
0.9
0.8 (0.02–11.12)
Allele
C
375 (90.2)
348 (83.7)
1
291 (91.5)
290 (84.3)
1
84 (85.7)
58 (80.6)
1
T
41 (9.8)
68 (16.3)
0.005
1.78 (1.18–2.71)
27 (8.5)
54 (15.7)
0.004
2.005 (1.23–3.31)
14 (14.3)
14 (19.4)
0.3
1.44 (0.63–3.3)
rs361525
(%)
(%)
(%)
(%)
(%)
(%)
GG
104 (50)
62 (29.8)
1
83 (51.2)
48 (27.9)
1
21 (42.9)
14 (38.9)
1
GA
80 (38.5)
110 (52.9)
0.0001
2.30 (1.50–3.53)
57 (35.9)
94 (54.7)
0.00001
2.84 (1.75–4.63)
23 (46.9)
16 (44.4)
0.9
1.04 (0.40–2.68)
AA
24 (11.5)
36 (17.3)
0.002
2.50 (1.37–4.63)
19 (11.9)
30 (17.4)
0.003
2.71 (1.38–5.41)
5 (10.2)
6 (16.7)
0.4
1.77 (0.43–7.50)
Allele
G
288 (69.2)
234 (56.25)
1
223 (70.1)
187 (54.4)
1
65 (66.3)
44 (61.1)
1
A
128 (30.8)
182 (43.75)
0.0001
1.74 (1.31–2.32)
95 (29.9)
157 (45.6)
0.00002
1.96 (1.43–2.71)
33 (33.7)
28 (38.9)
0.4
1.25 (0.66–2.36)
. The chi-square test was used to evaluate the significant association between disease (schizophrenia against controls) and TNFA or LTA alleles or genotypes. The Fisher exact test was used to determine whether significant differences were observed when the patient group was compared with the control group and having total less than 5.
