Anti-Double-Stranded DNA Isotypes and Anti-C1q Antibody Improve the Diagnostic Specificity of Systemic Lupus Erythematosus
Table 4
Concentrations (mean ± SEM, U/ml) of anti-dsDNA isotypes and anti-C1q antibody in active, inactive, LN, and non-LN SLE patients and active, inactive LN patients.
Activity of SLE ()
SLE with renal involvement ()
Activity of LN ()
Active SLE (U/ml)
Inactive SLE (U/ml)
value
LN (U/ml)
Non-LN (U/ml)
value
Active LN (U/ml)
Inactive LN (U/ml)
value
Anti-dsDNA IgG
116.66 ± 10.63
62.21 ± 11.27
0.001
95.57 ± 11.29
95.60 ± 12.17
NS
98.60 ± 13.40
88.90 ± 22.06
NS
Anti-dsDNA IgM
36.49 ± 5.99
34.20 ± 8.71
NS
26.14 ± 5.72
45.80 ± 8.16
0.037
26.61 ± 6.28
25.23 ± 11.90
NS
Anti-dsDNA IgA
44.39 ± 8.03
17.89 ± 5.61
0.003
29.45 ± 6.90
38.17 ± 8.53
NS
32.04 ± 9.44
23.13 ± 8.47
NS
Anti-C1q
29.36 ± 4.17
11.44 ± 2.79
0.000
23.07 ± 4.00
21.02 ± 4.12
NS
26.38 ± 5.52
16.62 ± 4.63
NS
SLE: systemic lupus erythematosus; LN: lupus nephritis; NS: no significance; , Mann–Whitney U test.
