Research Article

Anti-Double-Stranded DNA Isotypes and Anti-C1q Antibody Improve the Diagnostic Specificity of Systemic Lupus Erythematosus

Table 5

Diagnostic value of anti-dsDNA isotypes, anti-C1q antibody, and low C3 and/or C4 for SLE.

SensitivitySpecificityPPVNPVOR (95% CI)

Anti-dsDNA IgG75%93%88%84%37.667 (16.270–87.204)
Anti-dsDNA IgM45%97%92%69%23.731 (8.102–69.512)
Anti-dsDNA IgA33%97%89%65%14.625 (4.951–43.203)
Anti-C1q49%92%58%83%10.679 (4.917–23.193)
Low C3 and/or C481%59%62%79%6.097 (2.891–12.858)

SLE: systemic lupus erythematosus; PPV: positive predictive value; NPV: negative predictive value; OR: odds ratio; CI: confidence interval.