TY - JOUR
A2 - Ashwood, Paul
AU - Ferreira, Roberto Rodrigues
AU - Madeira, Fabiana da Silva
AU - Alves, Gabriel Farias
AU - Chambela, Mayara da Costa
AU - Curvo, Eduardo de Oliveira Vaz
AU - Moreira, Aline dos Santos
AU - Almeida de Sá, Renata
AU - Mendonça-Lima, Leila
AU - Cabello, Pedro Hernan
AU - Bailly, Sabine
AU - Feige, Jean-Jacques
AU - Araujo-Jorge, Tania Cremonini
AU - Saraiva, Roberto Magalhães
AU - Waghabi, Mariana Caldas
PY - 2018
DA - 2018/02/18
TI - TGF-β Polymorphisms Are a Risk Factor for Chagas Disease
SP - 4579198
VL - 2018
AB - Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population. We investigated five single-nucleotide polymorphisms (−800 G>A, −509 C>T, +10 T>C, +25 G>C, and +263 C>T). 152 patients with Chagas disease (53 with the indeterminate form and 99 with the cardiac form) and 48 noninfected subjects were included. Genotypes CT and TT at position −509 of the TGFB1 gene were more frequent in Chagas disease patients than in noninfected subjects. Genotypes TC and CC at codon +10 of the TGFB1 gene were also more frequent in Chagas disease patients than in noninfected subjects. We found no significant differences in the distribution of the studied TGFB1 polymorphisms between patients with the indeterminate or cardiac form of Chagas disease. Therefore, −509 C>T and +10 T>C TGFB1 polymorphisms are associated with Chagas disease susceptibility in a Brazilian population.
SN - 0278-0240
UR - https://doi.org/10.1155/2018/4579198
DO - 10.1155/2018/4579198
JF - Disease Markers
PB - Hindawi
KW -
ER -