TY - JOUR A2 - Ashwood, Paul AU - Ferreira, Roberto Rodrigues AU - Madeira, Fabiana da Silva AU - Alves, Gabriel Farias AU - Chambela, Mayara da Costa AU - Curvo, Eduardo de Oliveira Vaz AU - Moreira, Aline dos Santos AU - Almeida de Sá, Renata AU - Mendonça-Lima, Leila AU - Cabello, Pedro Hernan AU - Bailly, Sabine AU - Feige, Jean-Jacques AU - Araujo-Jorge, Tania Cremonini AU - Saraiva, Roberto Magalhães AU - Waghabi, Mariana Caldas PY - 2018 DA - 2018/02/18 TI - TGF-β Polymorphisms Are a Risk Factor for Chagas Disease SP - 4579198 VL - 2018 AB - Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases. We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population. We investigated five single-nucleotide polymorphisms (−800 G>A, −509 C>T, +10 T>C, +25 G>C, and +263 C>T). 152 patients with Chagas disease (53 with the indeterminate form and 99 with the cardiac form) and 48 noninfected subjects were included. Genotypes CT and TT at position −509 of the TGFB1 gene were more frequent in Chagas disease patients than in noninfected subjects. Genotypes TC and CC at codon +10 of the TGFB1 gene were also more frequent in Chagas disease patients than in noninfected subjects. We found no significant differences in the distribution of the studied TGFB1 polymorphisms between patients with the indeterminate or cardiac form of Chagas disease. Therefore, −509 C>T and +10 T>C TGFB1 polymorphisms are associated with Chagas disease susceptibility in a Brazilian population. SN - 0278-0240 UR - https://doi.org/10.1155/2018/4579198 DO - 10.1155/2018/4579198 JF - Disease Markers PB - Hindawi KW - ER -