Research Article

TGF-β Polymorphisms Are a Risk Factor for Chagas Disease

Table 3

Genotype and allele distribution of TGFB1 polymorphisms among noninfected subjects and patients with Chagas disease.

Chagas disease
(%)
Noninfected
(%)
OR (95% CI) value value after correction for multiple comparisons

−800 G/A
GenotypeGG134 (88.2)45 (93.75)Reference
AG17 (11.2)3 (6.25)1.69 (0.54–5.26)0.360.63
AA1 (0.65)0 (0.0)1.01 (0.09–11.46)0.990.99

AlleleG285 (93.75)93 (96.88)Reference
A19 (6.25)3 (3.13)1.82 (0.61–5.47)0.280.56

−509 C/T
GenotypeCC10 (6.6)15 (31.25)Reference
CT68 (44.7)16 (33.33)6.13 (2.41–15.58)<0.00010.00035
TT74 (48.7)17 (35.42)6.28 (2.49–15.83)<0.00010.00035

AlleleC88 (28.95)46 (47.92)Reference
T216 (71.05)50 (52.08)2.25 (1.40–3.60)0.00010.00035

+10 T/C
GenotypeTT14 (9.2)17 (35.42)Reference
TC93 (61.2)17 (35.42)6.64 (2.75–15.10)<0.00010.00035
CC45 (29.6)14 (29.17)3.90 (1.54–9.31)0.0030.008

AlleleT121 (39.80)51 (53.13)Reference
C183 (60.20)45 (46.88)1.71 (1.10–2.70)0.0220.05

+25 G/C
GenotypeGG131 (86.2)43 (89.58)Reference
CG20 (13.2)5 (10.42)1.23 (0.47–3.25)0.670.79
CC1 (0. 7)0 (0.0)1.01 (0.09–11.38)0.990.99

AlleleG282 (92.76)91 (94.79)Reference
C22 (7.24)5 (5.21)1.32 (0.52–3.35)0.550.79

+263 C/T
GenotypeCC145 (96.0)47 (97.92)Reference
CT6 (3.95)1 (2.08)1.41 (0.28–7.04)0.670.79
TT0 (0.0)0 (0.0)

AlleleC296 (98.03)95 (98.96)Reference
T6 (1.97)1 (1.04)1.40 (0.28–6.83)0.680.79