Research Article
TGF-β Polymorphisms Are a Risk Factor for Chagas Disease
Table 3
Genotype and allele distribution of TGFB1 polymorphisms among noninfected subjects and patients with Chagas disease.
| | | Chagas disease (%) | Noninfected (%) | OR (95% CI) | value | value after correction for multiple comparisons |
| | −800 G/A | Genotype | GG | 134 (88.2) | 45 (93.75) | Reference | | | AG | 17 (11.2) | 3 (6.25) | 1.69 (0.54–5.26) | 0.36 | 0.63 | AA | 1 (0.65) | 0 (0.0) | 1.01 (0.09–11.46) | 0.99 | 0.99 |
| Allele | G | 285 (93.75) | 93 (96.88) | Reference | | | A | 19 (6.25) | 3 (3.13) | 1.82 (0.61–5.47) | 0.28 | 0.56 |
| | −509 C/T | Genotype | CC | 10 (6.6) | 15 (31.25) | Reference | | CT | 68 (44.7) | 16 (33.33) | 6.13 (2.41–15.58) | <0.0001 | 0.00035 | TT | 74 (48.7) | 17 (35.42) | 6.28 (2.49–15.83) | <0.0001 | 0.00035 |
| Allele | C | 88 (28.95) | 46 (47.92) | Reference | | T | 216 (71.05) | 50 (52.08) | 2.25 (1.40–3.60) | 0.0001 | 0.00035 |
| | +10 T/C | Genotype | TT | 14 (9.2) | 17 (35.42) | Reference | | TC | 93 (61.2) | 17 (35.42) | 6.64 (2.75–15.10) | <0.0001 | 0.00035 | CC | 45 (29.6) | 14 (29.17) | 3.90 (1.54–9.31) | 0.003 | 0.008 |
| Allele | T | 121 (39.80) | 51 (53.13) | Reference | | C | 183 (60.20) | 45 (46.88) | 1.71 (1.10–2.70) | 0.022 | 0.05 |
| | +25 G/C | Genotype | GG | 131 (86.2) | 43 (89.58) | Reference | | CG | 20 (13.2) | 5 (10.42) | 1.23 (0.47–3.25) | 0.67 | 0.79 | CC | 1 (0. 7) | 0 (0.0) | 1.01 (0.09–11.38) | 0.99 | 0.99 |
| Allele | G | 282 (92.76) | 91 (94.79) | Reference | | C | 22 (7.24) | 5 (5.21) | 1.32 (0.52–3.35) | 0.55 | 0.79 |
| | +263 C/T | Genotype | CC | 145 (96.0) | 47 (97.92) | Reference | | CT | 6 (3.95) | 1 (2.08) | 1.41 (0.28–7.04) | 0.67 | 0.79 | TT | 0 (0.0) | 0 (0.0) | — | — | |
| Allele | C | 296 (98.03) | 95 (98.96) | Reference | | T | 6 (1.97) | 1 (1.04) | 1.40 (0.28–6.83) | 0.68 | 0.79 |
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