Research Article
SP110 Polymorphisms Are Genetic Markers for Vulnerability to Latent and Active Tuberculosis Infection in Taiwan
Table 3
Association analyses of SP110 SNP genotypes with LTBI and TB susceptibility.
(a) Association between SP110 SNP genotypes and LTBI risk in LTBI cases vs. healthy controls |
| | SNP ID | Genotypes | Health no. (%) | LTBI no. (%) | OR (95% CI) | value |
| | rs7580912 | AA | 134 (49) | 26 (43) | Ref | — | | GA | 111 (41) | 20 (33) | 0.884 (0.464-1.686) | 0.709 | | GG | 27 (10) | 14 (23) | 2.451 (1.12-5.364) | 0.025 | | rs7580900 | AA | 100 (37) | 16 (25) | Ref | — | | GA | 128 (47) | 29 (45) | 1.403 (0.716-2.749) | 0.324 | | GG | 43 (16) | 19 (30) | 2.584 (1.208-5.53) | 0.015 | | rs11556887 | CC | 206 (76) | 49 (77) | Ref | — | | CT | 64 (24) | 15 (23) | 0.982 (0.513-1.882) | 0.957 | | TT | 1 (0.4) | 0 (0) | <0.001 (<0.001-999.999) | 0.967 | | rs9061 | GG | 177 (65) | 54 (82) | Ref | — | | AA | 16 (6) | 0 (0) | <0.001 (<0.001-999.999) | 0.901 | | GA | 79 (29) | 12 (18) | 0.494 (0.239-0.981) | 0.044 | | rs3820974 | CC | 125 (46) | 34 (52) | Ref | — | | AA | 29 (11) | 6 (9) | 0.712 (0.269-1.886) | 0.494 | | CA | 118 (43) | 25 (38) | 0.703 (0.391-1.264) | 0.239 | | rs1365776 | AA | 217 (81) | 52 (83) | Ref | — | | GA | 47 (18) | 10 (16) | 0.757 (0.345-1.66) | 0.487 | | GG | 4 (1) | 1 (1) | 1.212 (0.129-11.39) | 0.867 | | rs41309108 | TT | 153 (56) | 41 (63) | Ref | — | | AA | 10 (4) | 1 (1) | 0.395 (0.048-3.248) | 0.387 | | TA | 109 (40) | 23 (35) | 0.768 (0.433-1.362) | 0.367 | | rs2241525 | GG | 186 (69) | 36 (58) | Ref | — | | AA | 10 (4) | 4 (7) | 1.984 (0.579-6.802) | 0.276 | | GA | 75 (28) | 22 (35) | 1.509 (0.828-2.75) | 0.179 | | rs1135791 | TT | 206 (75) | 48 (79) | Ref | — | | CC | 3 (1) | 0 (0) | <0.001 (<0.001-999.999) | 0.943 | | CT | 64 | 13 (21) | 0.86 (0.434-1.703) | 0.667 | | rs10498244 | AA | 199 (75) | 44 (83) | Ref | — | | AG | 61 (23) | 7 (13) | 0.523 (0.223-1.223) | 0.135 | | GG | 5 (2) | 2 (4) | 1.9 (0.354-10.203) | 0.454 |
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OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.
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(b) Association between SP110 SNP genotypes and TB risk in TB patients vs. LTBI cases |
| | SNP ID | Genotypes | Health no. (%) | LTBI No. (%) | OR (95% CI) | value |
| | rs7580912 | AA | 26 (43) | 129 (43) | Ref | — | | GA | 20 (33) | 139 (47) | 1.377 (0.731-2.595) | 0.322 | | GG | 14 (23) | 31 (10) | 0.392 (0.179-0.86) | 0.02 | | rs7580900 | AA | 16 (25) | 98 (33) | Ref | — | | GA | 29 (45) | 151 (50) | 0.863 (0.444-1.878) | 0.664 | | GG | 19 (30) | 50 (17) | 0.392 (0.182-0.848) | 0.017 | | rs11556887 | CC | 49 (77) | 248 (83) | Ref | — | | CT | 15 (23) | 47 (16) | 0.628 (0.324-1.219) | 0.169 | | TT | 0 (0) | 4 (1) | >999.999 (<0.001->999.999) | 0.988 | | rs9061 | GG | 54 (82) | 203 (68) | Ref | — | | AA | 0 (0) | 15 (5) | >999.999 (<0.001->999.999) | 0.974 | | GA | 12 (18) | 79 (27) | 1.831 (0.924-3.627) | 0.083 | | rs3820974 | CC | 34 (52) | 136 (45) | Ref | — | | AA | 6 (9) | 32 (11) | 1.261 (0.483-3.293) | 0.637 | | CA | 25 (38) | 131 (44) | 1.31 (0.739-2.323) | 0.356 | | rs1365776 | AA | 52 (83) | 240 (80) | Ref | — | | GA | 10 (16) | 51 (17) | 1.264 (0.58-2.753) | 0.556 | | GG | 1 (1) | 8 (3) | 2.028 (0.244-16.888) | 0.513 | | rs41309108 | TT | 41 (63) | 176 (59) | Ref | — | | AA | 1 (1) | 12 (4) | 2.401 (0.3-19.219) | 0.409 | | TA | 23 (35) | 111 (37) | 1.096 (0.621-1.932) | 0.753 | | rs2241525 | GG | 36 (58) | 211 (71) | Ref | — | | AA | 4 (7) | 12 (4) | 0.47 (0.142-1.562) | 0.218 | | GA | 22 (35) | 73 (25) | 0.564 (0.31-1.026) | 0.061 | | rs1135791 | TT | 48 (79) | 212 (71) | Ref | — | | CC | 0 (0) | 5 (2) | >999.999 (<0.001->999.999) | 0.986 | | CT | 13 (21) | 82 (27) | 1.33 (0.68-2.602) | 0.404 | | rs10498244 | AA | 44 (83) | 215 (72) | Ref | — | | AG | 7 (13) | 80 (27) | 2.137 (0.917-4.981) | 0.079 | | GG | 2 (4) | 4 (1) | 0.441 (0.074-2.62) | 0.368 |
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OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.
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(c) Association between SP110 SNP genotypes and TB risk in TB patients vs. healthy controls |
| | SNP ID | Genotypes | Health no. (%) | LTBI no. (%) | OR (95% CI) | value |
| | rs7580912 | AA | 134 (49) | 129 (43) | Ref | — | | GA | 111 (41) | 139 (47) | 1.258 (0.869-1.822) | 0.224 | | GG | 27 (10) | 31 (10) | 0.877 (0.474-1.622) | 0.676 | | rs7580900 | AA | 100 (37) | 98 (33) | Ref | — | | GA | 128 (47) | 151 (50) | 1.258 (0.851-1.86) | 0.249 | | GG | 43 (16) | 50 (17) | 1.023 (0.601-1.74) | 0.934 | | rs11556887 | CC | 206 (76) | 248 (83) | Ref | — | | CT | 64 (23.6) | 47 (16) | 0.626 (0.401-0.976) | 0.039 | | TT | 1 (0.4) | 4 (1) | 2.387 (0.243-23.458) | 0.456 | | rs9061 | GG | 176 (65) | 203 (68) | Ref | — | | AA | 17 (6) | 15 (5) | 0.792 (0.36-1.742) | 0.561 | | GA | 79 (29) | 79 (27) | 0.886 (0.597-1.313) | 0.546 | | rs3820974 | CC | 125 (46) | 136 (45) | Ref | — | | AA | 29 (11) | 32 (11) | 0.871 (0.473-1.603) | 0.657 | | CA | 118 (43) | 131 (44) | 0.942 (0.651-1.363) | 0.749 | | rs1365776 | AA | 217 (81) | 240 (80) | Ref | — | | GA | 47 (18) | 51 (17) | 0.931 (0.582-1.489) | 0.767 | | GG | 4 (2) | 8 (3) | 2.291 (0.631-8.322) | 0.208 | | rs41309108 | TT | 153 (56) | 176 (59) | Ref | — | | AA | 9 (3) | 12 (4) | 0.982 (0.382-2.527) | 0.971 | | TA | 109 (40) | 111 (37) | 0.852 (0.593-1.225) | 0.387 | | rs2241525 | GG | 186 (69) | 211 (71) | Ref | — | | AA | 10 (3) | 12 (4) | 1.004 (0.402-2.505) | 0.994 | | GA | 75 (28) | 73 (25) | 0.85 (0.569-1.268) | 0.425 | | rs1135791 | TT | 206 (75) | 212 (71) | Ref | — | | CC | 3 (1) | 5 (2) | 1.681 (0.371-7.617) | 0.5 | | CT | 64 (24) | 82 (27) | 1.177 (0.788-1.76) | 0.426 | | rs10498244 | AA | 199 (75) | 215 (72) | Ref | — | | AG | 61 (23) | 80 (27) | 1.185 (0.787-1.785) | 0.417 | | GG | 5 (2) | 4 (1) | 0.774 (0.191-3.133) | 0.719 |
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OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.
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