Research Article

The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

Figure 3

CES2 activity in human colorectal cancer and adjacent normal tissues was quantified by ABPP. (a) CES2 activities of HEK293T cells (mock versus CES2 overexpression), colorectal cancer cells (RKO and LS174T cells; control versus nutlin-3a), and representative human colorectal samples were shown. (b) CES2 activity was significantly decreased in the tumor tissue. by paired two-tailed t-test. (c) The CES2 activities were compared between tumors with TP53 mutations generating nonfunctional p53 protein and tumors without TP53 mutations. ; . A Tukey-Kramer test was used.
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