Does the Risk of Ovarian Malignancy Algorithm Provide Better Diagnostic Performance Than HE4 and CA125 in the Presurgical Differentiation of Adnexal Tumors in Polish Women?

Table 6

AUCs with statistical differences and optimal cut-offs of tumor markers and ROMA for the differentiation of stage I FIGO malignant adnexal tumors and epithelial ovarian cancer from nonmalignant adnexal tumors.

Diagnostic test	Stage I FIGO malignant adnexal tumors versus nonmalignant adnexal tumors			Epithelial ovarian cancer versus nonmalignant adnexal tumors
	AUC (95% CI)	value	Optimal cut-off	AUC (95% CI)	value	Optimal cut-off
HE4	0.802 (0.695–0.910)	<0.001	56	0.928 (0.882–0.974)	<0.001	72.1
CA125	0.559 (0.388–0.731)	0.427	—	0.858 (0.781–0.935)	<0.001	54.4
ROMA	0.789 (0.679–0.898)	<0.001	10.5	0.929 (0.882–0.976)	<0.001	18.3

AUC: area under the curve; FIGO: Fédération Internationale de Gynécologie et d’Obstétrique; CI: confidence interval; ROMA: Risk of Ovarian Malignancy Algorithm.