Does the Risk of Ovarian Malignancy Algorithm Provide Better Diagnostic Performance Than HE4 and CA125 in the Presurgical Differentiation of Adnexal Tumors in Polish Women?

Table 7

Results of the Hanley and McNeil test comparing the AUC of the diagnostic tests HE4, CA125, and ROMA for the differentiation of malignant from nonmalignant adnexal tumors.

Compared tests	Malignant versus nonmalignant among the whole group	Malignant versus non-malignant among the premenopausal subgroup	Malignant versus nonmalignant among the postmenopausal subgroup	Stage I FIGO malignant versus nonmalignant adnexal tumors	Epithelial ovarian cancer versus nonmalignant adnexal masses
HE4 versus CA125 ( value)	0.043	0.314	0.618	0.017	0.118
HE4 versus ROMA ( value)	0.999	0.985	0.965	0.893	0.979
CA125 versus ROMA ( value)	0.043	0.324	0.587	0.025	0.112

AUC: area under the curve; FIGO: Fédération Internationale de Gynécologie et d’Obstétrique; ROMA: Risk of Ovarian Malignancy Algorithm.