Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis

Table 2

Characteristics of studies and lncRNAs expression related to DFS in GIC patients.

References	lncRNAs ()	Year	Nations	Number ()	DFS		Cut-off value	Detection methods	Sample types	Follow-up
					HR	95% CI
Kong et al. [15]^!	PVT1^↑	2015	China	80GC	2.22	1.13–4.44	Median	RT-PCR	Tissue	<40
Liu et al. [17]	FEZF1-AS1^↑	2017	China	82GC	1.52^#	0.88–2.63	2-fold	RT-PCR	Tissue	1–43^#
Fan et al. [30]	LINC00261^↓	2016	China	138GC	1.81	1.06–3.10	Median	RT-PCR	Tissue	20–48
Xu et al. [34]	PVT1^↑	2017	China	190GC	1.75	1.25–2.56	Mean	RT-PCR	Tissue	1–85
Yuan et al. [35]^!	PVT1^↑	2016	China	111GC	2.21	1.11–4.40	Median	RT-PCR	Tissue	20–48
Zheng et al. [37]^!	UCA1^↑	2015	China	112GC	2.55	1.33–4.97	Dichotomize	RT-PCR	Tissue	<92
Wang et al. [39]^!	CCAT2^↑	2016	China	108GC	2.31	1.55–3.42	Median	RT-PCR	Tissue	<70
Yue et al. [42]^!	FER1L4^↓	2015	China	70CC	4.51	1.99–9.02	Median	RT-PCR	Tissue	<80
Chen et al. [48]^!	H19^↑	2016	China	128GC	1.29	1.00-1.65	Median	RT-PCR	Tissue	20–48
Zou et al. [49]^!	Sox2ot^↑	2016	China	155GC	3.84	1.87–7.33	Median	RT-PCR	Tissue	<70
Wang et al. [24]	NR_034119^↓	2016	China	107CRC	1.93	1.04–3.61	NR	RT-PCR	Serum	11–74
Wang et al. [52]^!	OTUB1-isoform 2^↑	2016	China	156GC	1.50	1.02–2.20	Median	RT-PCR	Tissue	<80
Liu et al. [59]^!	DANCR^↑	2015	China	104CRC	2.40	1.39–7.28	Median	RT-PCR	Tissue	<60
Wang et al. [60]^!	ZEB1-AS1^↑	2015	China	87EC	2.7	1.38–8.35	Median	RT-PCR	Tissue	<61
Ma et al. [62]^!	PANDAR^↑	2016	China	100GC	2.36	1.15–4.83	NR	RT-PCR	Tissue	2–36
Peng et al. [65]^!	NEAT1^↑	2016	China	56CRC	2.39^#	1.37–4.19	NR	RT-PCR	Tissue	<60
Zhou et al. [69]^!	ROR^↑	2016	China	60CC	5.64	1.92–16.58	Median	RT-PCR	Tissue	<80
Yang et al. [70]^!	Loc554202^↓	2016	China	178CRC	2.75	1.55–7.93	Median	RT-PCR	Tissue	<70
Peng et al. [75]^!	SPRY4-IT1^↑	2015	China	175GC	1.74	1.32–2.48	Median	RT-PCR	Tissue	<60
Nie et al. [76]^!	ZFAS1^↑	2016	China	54GC	1.83^#	1.07–3.15	Median	RT-PCR	Tissue	3–36^#
Xu et al. [79]^a	LSINCT5^↑	2014	China	71GC	1.08	1.29–3.56	Mean	RT-PCR	Tissue	<72
				74CRC	1.30	1.11–3.84	Mean	RT-PCR	Tissue	<72
Sun et al. [80]^!	RP11-119F7.4^↓	2015	China	96GC	1.16^#	0.81–1.65	Median	RT-PCR	Tissue	<100
Zhang et al. [81]^!	ANRIL^↑	2014	China	120GC	1.72	1.04–2.84	3-fold	RT-PCR	Tissue	<60
Li et al. [82]^!	NEAT1^↑	2015	China	239CRC	1.80	1.27–2.55	2-fold	RT-PCR	Tissue	<60
Han et al. [84]^!	H19^↑	2016	China	83CRC	1.52	1.30–1.90	3-fold	RT-PCR	Tissue	<50
Cao et al. [87]^!	BC200^↑	2016	China	70EC	2.17	1.12–4.19	Median	RT-PCR	Tissue	<50
Wang et al. [90]^!	AFAP1-AS1^↑	2016	China	52CRC	2.12	1.03-4.35	Median	RT-PCR	Tissue	<50
Sun et al. [93]^!	AK098081^↑	2016	China	84CRC	1.40^#	0.86–2.28	Mean	RT-PCR	Tissue	1–118^#
Xu et al. [94]^!	FENDRR^↓	2014	China	158GC	1.8	1.11–2.91	Median	RT-PCR	Tissue	20–48
Shang et al. [95]	UCA1^↑	2016	China	77GC	2.54	1.09–5.92	NR	RT-PCR	Tissue	<60
Fei et al. [103]^!	LINC00982^↓	2016	China	106GC	2.40	1.19--4.81	Median	RT-PCR	Tissue	20–48
Chen et al. [104]^!	SNHG15^↑	2016	China	106GC	2.40	1.38–4.18	Median	RT-PCR	Tissue	20–48
Liu et al. [108]^!	BANCR^↑	2016	China	142EC	3.42^#	2.29–5.10	Median	RT-PCR	Tissue	1–60^#
Wu et al. [113]^!	GHRLOS^↓	2017	China	366CRC	2.02	1.42–2.88	1/2-fold	RT-PCR	Tissue	5–85
Yu et al. [114]	linc00261^↓	2017	China	80GC	2.57	1.39–4.20	NR	RT-PCR	Tissue	<30
Ba et al. [120]	LINC00673^↑	2017	China	79GC	2.94	1.23–4.21	Median	RT-PCR	Tissue	<50
Xu et al. [123]	FOXD2-AS1^↑	2018	China	106GC	1.75	1.04–2.97	Median	RT-PCR	Tissue	20–48

^aOne study involved GC and CRC. indicates adjusted HR; # indicates calculated HR of DFS and follow-up time; ! indicates studies included OS and DFS; ↑ or ↓ indicates upregulated or downregulated with poor prognosis. OS: overall survival; DFS: disease-free survival; HR: hazard ratio; CI: confidence interval; EC: esophageal cancer; GC: gastric cancer; CRC: colorectal cancer; GIC: gastrointestinal cancer; NR: no report; RT-PCR: reverse transcription PCR.