A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease
Table 3
Genotype frequencies for SNPs of the CYP4A11 and CYP4F2 genes in patients with CAD and healthy controls stratified by gender.
Gene, polymorphism
Genotype
Males, (%)1
Females, (%)1
Controls,
CAD patients,
value
value
adjOR (95% CI)2
Controls,
CAD patients,
value
value
adjOR (95% CI)2
CYP4A11, C>G (rs3890011)
C/C
228 (56.4)
224 (55.9)
0.98
0.98
1.00
176 (62.4)
114 (48.3)
0.004
0.01
1.00
C/G
144 (35.6)
144 (35.9)
1.01 (0.76–1.37)
92 (32.6)
100 (42.4)
1.62 (1.14–2.39)
G/G
32 (7.9)
33 (8.2)
1.04 (0.61–1.77)
14 (5.0)
22 (9.3)
2.66 (1.29–5.46)
CYP4A11, T>C (rs9332978)
T/T
313 (77.5)
297 (74.1)
0.45
0.98
1.00
229 (81.2)
162 (69.2)
0.004
0.01
1.00
T/C
86 (21.3)
96 (23.9)
1.18 (0.85–1.62)
48 (17.0)
62 (26.5)
1.85 (1.21–2.82)
C/C
5 (1.2)
8 (2.0)
1.69 (0.52–5.24)
5 (1.8)
10 (4.3)
3.09 (1.02–9.35)
CYP4A11, A>G (rs9333029)
A/A
300 (74.4)
302 (75.3)
0.77
0.98
1.00
226 (80.4)
175 (74.2)
0.12
0.20
1.00
A/G
103 (25.6)
99 (24.7)
0.98 (0.62–1.47)
55 (19.6)
61 (25.8)
1.44 (0.89–2.76)
G/G
0 (0.0)
0 (0.0)
—
0 (0.0)
0 (0.0)
—
CYP4F2, A>G (rs3093098)
A/A
277 (68.6)
278 (69.3)
0.33
0.98
1.00
202 (71.6)
170 (72.0)
0.54
0.54
1.00
A/G
112 (27.7)
115 (28.7)
1.02 (0.74–1.39)
74 (26.2)
57 (24.2)
0.93 (0.61–1.84)
G/G
15 (3.7)
8 (2.0)
0.55 (0.24–1.35)
6 (2.1)
9 (3.8)
1.72 (0.61–5.97)
CYP4F2, G>A (rs1558139)
G/G
124 (30.7)
124 (30.9)
0.95
0.98
1.00
76 (27.0)
68 (28.8)
0.46
0.54
1.00
G/A
194 (48.0)
188 (46.9)
0.96 (0.72–1.38)
142 (50.4)
124 (52.5)
1.02 (0.64–1.85)
A/A
86 (21.3)
89 (22.2)
1.04 (0.72–1.56)
64 (22.7)
44 (18.6)
0.77 (0.44–1.34)
1Absolute number and percentage of individuals with particular genotype. 2Odds ratio with 95% confidence intervals adjusted for age, BMI, hypertension, diabetes, and smoking.
