A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease
Table 4
Epistatic interactions between the CYP4A11 and CYP4F2 genes in CAD (gene-gene interactions are evaluated by SNPassoc package for R [31]).
SNPs
Genetic models
CYP4A11 (rs3890011)
CYP4A11 (rs9332978)
CYP4A11 (rs9333029)
CYP4F2 (rs3093098)
CYP4F2 (rs1558139)
CYP4A11 (rs3890011)
Сodominant
0.086
0.459
0.725
0.598
0.435
Dominant
0.035
0.712
0.450
0.319
0.533
Recessive
0.180
0.159
—
0.986
0.594
Overdominant
0.152
0.879
0.168
0.899
0.844
CYP4A11 (rs9332978)
Сodominant
0.933
0.008
0.396
0.194
0.226
Dominant
0.768
0.004
0.885
0.156
0.512
Recessive
0.608
0.063
—
—
0.025
Overdominant
0.824
0.019
0.935
0.307
0.686
CYP4A11 (rs9333029)
Сodominant
0.477
0.371
0.433
0.902
0.216
Dominant
0.534
0.398
0.433
0.835
0.098
Recessive
—
—
—
—
—
Overdominant
0.899
0.441
0.433
0.743
0.134
CYP4F2 (rs3093098)
Сodominant
0.849
0.837
0.866
0.894
0.096
Dominant
0.627
0.592
0.711
0.775
0.152
Recessive
0.675
0.703
—
0.661
—
Overdominant
0.808
0.718
0.838
0.897
0.047
CYP4F2 (rs1558139)
Сodominant
0.890
0.923
0.918
0.806
0.912
Dominant
0.715
0.807
0.718
0.668
0.733
Recessive
0.701
0.764
—
0.686
0.717
Overdominant
0.998
0.913
0.940
0.991
0.989
The upper part of the matrix contains the values for epistatic interactions evaluated by log-likelihood ratio (LRT) test. The diagonal contains the values from LRT for the crude effect of each SNP. The lower triangle contains the values from LRT comparing the two-SNP additive likelihood to the best of the single-SNP models. Bolded are statistically significant values for SNP-SNP interactions (most significant value for a particular model). values are adjusted for age and gender.
