A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease
Table 5
Estimated haplotype frequencies of CYP4A11 in CAD patients and controls.
Haplotypes1
Controls
CAD patients
OR (95% CI)2
value
SNPs C>G (rs3890011), T>C (rs9332978), and A>G (rs9333029) of CYP4A11
H1
C-T-A
0.7549
0.7158
1.00
—
H2
G-C-A
0.1060
0.1433
1.41 (1.12–1.78)
0.0036
H3
G-T-G
0.1087
0.1146
1.15 (0.88–1.50)
0.30
H4
G-T-A
0.0207
0.0135
0.67 (0.37–1.22)
0.19
Global haplotype association value: 0.021
SNPs A>G (rs3093098) and G>A (rs1558139) of CYP4F2
H1
A-A
0.4636
0.4525
1.00
—
H2
A-G
0.3703
0.3858
1.05 (0.91–1.27)
0.49
H3
G-G
0.1662
0.1605
0.97 (0.78–1.24)
0.85
Global haplotype association value: 0.72
Rare haplotypes with frequency < 0.01 are not shown. Odds ratio with 95% confidence intervals adjusted for age, gender, BMI, diabetes, and hypertension. Bolded is statistically significant value.
