Cell-Free Circulating Methylated SEPT9 for Noninvasive Diagnosis and Monitoring of Colorectal Cancer

Table 1

Demographic and clinicopathologic characteristics of enrolled subjects for evaluating diagnostic value of plasma mSEPT9.

Characteristics	N	Gender		Age				Location
		Male	Female	<50	50–59	60–69	≥70	Colon	Rectum
CRC	98	61	37	14	22	29	33	18	80
Stage 0	3	2	1	1	1	0	1	1	2
Stage I	23	16	7	4	7	4	8	7	16
Stage II	31	20	11	5	4	10	12	4	27
Stage III	31	19	12	2	9	11	9	5	26
Stage IV	8	3	5	2	0	3	3	1	7
Unknown	2	1	1	0	1	1	0	0	2
Adenomas	101	71	30	30	21	34	16	84	17
Noncolorectal cancer	76	15	61	33	18	17	8	NA	NA
Gastric cancer	10	8	2	0	0	4	6	NA	NA
Breast cancer	58	0	58	31	15	12	0	NA	NA
Others	8	7	1	2	3	1	2	NA	NA
Inflammation	30	14	16	8	7	13	2	NA	NA
Gastroenteritis	26	13	13	8	5	14	2	NA	NA
Others	4	1	3	0	2	2	0	NA	NA
NED	253	139	114	32	144	54	23	NA	NA
Total	558	300	258	117	212	147	82	NA	NA

CRC: colorectal cancer; NED: no evidence of diseases; NA: not applicable.