Biomarkers in Urachal Cancer and Adenocarcinomas in the Bladder: A Comprehensive Review Supplemented by Own Data

Figure 3

A representative case of mucinous urachal adenocarcinoma. (a) Atypical cells floating in extracellular mucin. Focal signet ring cell morphology is noticeable (H&E staining). The case exhibited a typical profile in further immunohistochemical studies with no reactivity for CK7 (b) but positive reactivity for CK20 (c) and CDX2 (d, nuclear). As in all analyzed cases, no GATA3 reactivity was noted (e). In the β-Catenin immunohistochemistry, a strong membranous and cytoplasmic but no nuclear reactivity was noted (f; inlay magnification 600x). The immunohistochemical reactions against the MMR proteins all were positive, that is, MLH1 (g), PMS2 (h), MSH2 (i), and MSH6 (j).

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