A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients

Table 1

The main characteristics of studies included in the meta-analysis.

Author	Year	Cancer type	Country	Ethnicity	Control	Genotype	of case	of control	HWE (P)
Kanamori et al. [7]	1999	Ovarian cancer	Japan	Asian	HB	PCR-RFLP	163	150	0.033
Biondi et al. [8]	2000	Other cancer	Italy	Caucasian	HB	TaqMan	160	164	0.813
Nishioka et al. [9]	2000	Endometrial cancer	Japan	Asian	HB	Sequencing	100	150	0.033
Ye et al. [10]	2001	Cutaneous melanoma	England	Caucasian	HB	TaqMan	139	132	0.849
Zhu et al. [11]	2001	Lung cancer	America	Caucasian	HB	PCR-RFLP	456	451	0.028
Ghilardi et al. [12]	2002	Breast cancer	America	Caucasian	HB	Sequencing	86	110	0.652
Hinoda et al. [13]	2002	Colorectal cancer	Japan	Asian	PB	PCR-RFLP	101	127	0.949
Hirata et al. [14]	2003	Renal cell cancer	Japan	Asian	HB	Sequencing	119	210	0.993
Nishioka et al. [15]	2003	Endometrial cancer	Japan	Asian	HB	Sequencing	109	150	0.033
Wenham et al. [16]	2003	Ovarian cancer	America	Caucasian	PB	TaqMan	311	387	0.536
Hashimoto et al. [17]	2004	Head and neck cancer	Japan	Asian	HB	PCR-RFLP	140	223	0.852
Hirata et al. [18]	2004	Renal cell cancer	Japan	Asian	PB	PCR-RFLP	156	230	0.871
Lin et al. [19]	2004	Oral cancer	Taiwan	Asian	HB	Sequencing	121	147	0.336
Matsumura et al. [20]	2004	Gastric cancer	Japan	Asian	HB	PCR-RFLP	215	166	0.432
Zinzindohoué et al. [21]	2004	Head and neck cancer	France	Caucasian	HB	PCR-RFLP	125	249	0.978
Fang et al. [22]	2005	Lung cancer	China	Asian	HB	PCR-RFLP	243	350	0.000
Jin et al. [23]	2005	Gastric cancer	China	Asian	HB	PCR-RFLP	417	350	0.000
Ju et al. [24]	2005	Cervical cancer	Korea	Asian	HB	TaqMan	232	332	0.695
Lai et al. [25]	2005	Cervical cancer	Taiwan	Asian	HB	Other	197	197	1.000
McCready et al. [26]	2005	Glioblastoma	America	Caucasian	HB	PCR-RFLP	81	57	0.916
Cao and Li [27]	2006	Oral cancer	China	Asian	HB	PCR-RFLP	96	120	0.657
Elander et al. [28]	2006	Colorectal cancer	Sweden	Caucasian	HB	Other	127	208	0.918
Kader et al. [29]	2006	Bladder cancer	America	Caucasian	HB	TaqMan	556	555	0.565
Li et al. [30]	2006	Ovarian cancer	China	Asian	HB	PCR-RFLP	122	151	0.008
Lièvre et al. [31]	2006	Colorectal cancer	France	Caucasian	HB	Other	591	561	0.900
O-charoenrat et al. [32]	2006	Head and neck cancer	Thailand	Asian	HB	PCR-RFLP	300	300	0.988
Su et al. [33]	2006	Lung cancer	America	Caucasian	PB	TaqMan	2014	1323	0.597
Sugimoto et al. [34]	2006	Endometrial cancer	Japan	Asian	HB	PCR-RFLP	107	213	0.768
Xu et al. [35]	2006	Colorectal cancer	China	Asian	HB	Other	126	126	0.938
Albayrak et al. [36]	2007	Prostate cancer	Turkey	Caucasian	HB	PCR-RFLP	55	43	0.000
Ju et al. [37]	2007	Ovarian cancer	Korea	Asian	HB	TaqMan	133	332	0.695
Lei et al. [38]	2007	Breast cancer	Sweden	Caucasian	PB	TaqMan	954	947	0.151
Lu et al. [39]	2007	Other cancer	China	Asian	HB	PCR-RFLP	221	366	0.000
Nasr et al. [40]	2007	Nasopharyngeal cancer	Tunisia	Caucasian	HB	PCR-RFLP	174	171	0.091
Nishizawa et al. [41]	2007	Oral cancer	Japan	Asian	HB	TaqMan	170	164	0.493
Piccoli et al. [42]	2007	Renal cell carcinoma	Brazil	Caucasian	PB	PCR-RFLP	99	118	1.000
Vairaktaris et al. [43]	2007	Oral cancer	Greek	Caucasian	HB	PCR-RFLP	156	141	0.276
Woo et al. [44]	2007	Colorectal cancer	Korea	Asian	HB	PCR-RFLP	185	304	0.488
Zhai et al. [45]	2007	Hepatocellular cancer	China	Asian	HB	Sequencing	431	479	0.559
Zhou et al. [46]	2007	Nasopharyngeal cancer	China	Caucasian	PB	Sequencing	829	759	0.634
Dos Reis et al. [47]	2008	Prostate cancer	Brazil	Caucasian	PB	TaqMan	100	100	0.293
González-Arriaga et al. [48]	2008	Lung cancer	Spain	Caucasian	HB	PCR-RFLP	501	510	0.934
Kouhkan et al. [49]	2008	Colorectal cancer	Iran	Asian	HB	PCR-RFLP	150	100	0.935
Shimizu et al. [50]	2008	Tongue cancer	Japan	Asian	HB	TaqMan	69	91	0.585
Tasci et al. [51]	2008	Bladder cancer	Turkey	Caucasian	HB	PCR-RFLP	102	94	0.740
Bradbury et al. [52]	2009	Esophageal cancer	America	Caucasian	HB	TaqMan	313	450	0.508
de Lima et al. [53]	2009	Colorectal cancer	Brazil	Caucasian	HB	PCR-RFLP	108	108	0.258
dos Reis et al. [54]	2009	Prostate cancer	Brazil	Caucasian	HB	TaqMan	100	100	0.293
Ricketts et al. [55]	2009	Renal cell cancer	Polish	Caucasian	HB	TaqMan	323	314	0.847
Srivastava et al. [56]	2010	Bladder cancer	India	Asian	HB	PCR-RFLP	200	200	0.190
Tsuchiya et al. [57]	2009	Prostate cancer	Japan	Asian	PB	Sequencing	283	251	0.285
Vairaktaris et al. [58]	2009	Oral cancer	Greek	Caucasian	HB	PCR-RFLP	156	141	0.276
Altaş et al. [59]	2010	Other cancer	Turkey	Caucasian	HB	PCR-RFLP	30	30	0.195
Chaudhary et al. [60]	2010	Head and neck cancer	India	Asian	HB	PCR-RFLP	422	426	0.240
Fang et al. [61]	2010	Colorectal cancer	China	Asian	HB	PCR-RFLP	237	252	0.683
Okamoto et al. [62]	2010	Hepatocellular cancer	Japan	Asian	HB	PCR-RFLP	91	82	0.009
Hart et al. [63]	2011	Lung cancer	Norway	Caucasian	PB	TaqMan	436	434	0.218
Liu et al. [64]	2011	Lung cancer	China	Asian	HB	PCR-RFLP	825	825	0.924
Malik et al. [65]	2011	Glioblastoma	India	Asian	HB	PCR-RFLP	110	150	0.433
Wang et al. [66]	2011	Cutaneous melanoma	America	Caucasian	HB	TaqMan	864	849	0.940
Cheung et al. [67]	2012	Esophageal cancer	Canada	Caucasian	HB	TaqMan	309	279	0.974
Enewold et al. [68]	2012	Lung cancer	America	Caucasian	HB	Other	71	147	0.743
Fakhoury et al. [69]	2012	Lung cancer	Lebanon	Caucasian	HB	PCR-RFLP	41	51	0.218
Wieczorek et al. [70]	2013	Bladder cancer	Poland	Caucasian	HB	TaqMan	240	199	0.022
Brzóska et al. [71]	2014	Lung cancer	Poland	Caucasian	HB	PCR-RFLP	53	54	0.264
Dedong et al. [72]	2014	Gastric cancer	China	Asian	HB	Other	422	428	0.546
Devulapalli et al. [73]	2014	Gastric cancer	India	Asian	HB	PCR-RFLP	166	202	0.000
Dey et al. [74]	2014	Gastric cancer	India	Caucasian	HB	PCR-RFLP	145	145	0.850
Guan et al. [75]	2014	Esophageal cancer	China	Asian	HB	PCR-RFLP	132	132	0.989
Kawal et al. [76]	2016	Breast cancer	Taiwan	Asian	HB	PCR-RFLP	1232	1232	0.004
Pei et al. [77]	2016	Other cancer	Taiwan	Asian	HB	PCR-RFLP	266	266	0.258
Su et al. [78]	2016	Breast cancer	Taiwan	Asian	HB	PCR-RFLP	1232	1232	0.004
Sun et al. [79]	2016	Oral cancer	Taiwan	Asian	HB	PCR-RFLP	788	956	0.029
Tsai et al. [80]	2016	Nasopharyngeal cancer	Taiwan	Asian	HB	PCR-RFLP	176	352	0.278
Lai et al. [81]	2017	Hepatocellular cancer	Taiwan	Asian	HB	PCR-RFLP	298	889	0.008
Padala et al. [82]	2017	Breast cancer	India	Asian	HB	PCR-RFLP	300	300	0.015
Yang et al. [83]	2017	Gastric cancer	Taiwan	Asian	HB	PCR-RFLP	121	363	0.131

HWE: Hardy–Weinberg equilibrium.