Research Article
High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients
Table 1
Patient characteristics and M30 serum measurements at ICU admission.
| | Parameter | All patients | Nonsepsis | Sepsis |
| | Number | 243 | 87 | 156 | | Sex (male/female) | 154/89 | 55/32 | 99/57 | | Age median (range) (years) | 64 (18–90) | 61 (18–85) | 65 (21–90) | | APACHE II score median (range) | 18 (2–43) | 17 (2–34) | 19 (3–43) | | ICU days median (range) | 7 (1–70) | 5 (1–44) | 10 (1–70) | | Death during ICU n (%) | 64 (26%) | 15 (17%) | 49 (31%) | | Death during follow-up (total) n (%) | 115 (47%) | 29 (33%) | 86 (55%) | | Mechanical ventilation n (%) | 168 (69%) | 55 (63%) | 113 (72%) | | Preexisting diabetes n (%) | 73 (30%) | 30 (35%) | 43 (28%) | | Preexisting cirrhosis n (%) | 25 (10%) | 16 (18%) | 9 (6%) | | BMI median (range) (m2/kg) | 25.9 (15.3–86.5) | 25.4 (15.9–53.3) | 26.0 (15.3–86.5) | | WBC median (range) (×103/μL) | 12.8 (0–208) | 11.9 (2.5–27.7) | 13.1 (0–208) | | CRP median (range) (mg/dL) | 93 (0–230) | 18 (5–230) | 153.3 (0–230) | | Procalcitonin median (range) (μg/L) | 1.2 (0–207.5) | 0.35 (0.03–100) | 3.4 (0–207.5) | | Creatinine median (range) (mg/dL) | 1.3 (0–21.6) | 1.0 (0.2–15) | 1.6 (0–21.6) | | INR median (range) | 1.17 (0–133) | 1.15 (0.9–6.73) | 1.18 (0–133) | | M30 median (range) (U/L) | 178.3 (16.7–1001) | 161.8 (21.6–1000) | 193.6 (16.7–1001) |
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For quantitative variables, median and range (in parenthesis) are given.
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