Disease Markers / 2018 / Article / Tab 1

Research Article

High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients

Table 1

Patient characteristics and M30 serum measurements at ICU admission.

ParameterAll patientsNonsepsisSepsis

Number24387156
Sex (male/female)154/8955/3299/57
Age median (range) (years)64 (18–90)61 (18–85)65 (21–90)
APACHE II score median (range)18 (2–43)17 (2–34)19 (3–43)
ICU days median (range)7 (1–70)5 (1–44)10 (1–70)
Death during ICU n (%)64 (26%)15 (17%)49 (31%)
Death during follow-up (total) n (%)115 (47%)29 (33%)86 (55%)
Mechanical ventilation n (%)168 (69%)55 (63%)113 (72%)
Preexisting diabetes n (%)73 (30%)30 (35%)43 (28%)
Preexisting cirrhosis n (%)25 (10%)16 (18%)9 (6%)
BMI median (range) (m2/kg)25.9 (15.3–86.5)25.4 (15.9–53.3)26.0 (15.3–86.5)
WBC median (range) (×103/μL)12.8 (0–208)11.9 (2.5–27.7)13.1 (0–208)
CRP median (range) (mg/dL)93 (0–230)18 (5–230)153.3 (0–230)
Procalcitonin median (range) (μg/L)1.2 (0–207.5)0.35 (0.03–100)3.4 (0–207.5)
Creatinine median (range) (mg/dL)1.3 (0–21.6)1.0 (0.2–15)1.6 (0–21.6)
INR median (range)1.17 (0–133)1.15 (0.9–6.73)1.18 (0–133)
M30 median (range) (U/L)178.3 (16.7–1001)161.8 (21.6–1000)193.6 (16.7–1001)

For quantitative variables, median and range (in parenthesis) are given.