Research Article
ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population
Table 2
Genotype frequency distribution of ABCC4 in KD patients and healthy controls.
| | Genotype | Patients () | Controls () | valuea | OR (95% CI) | value | Adjusted OR (95% CI) | valueb |
| | ABCC4/rs7986087 C > T (HWE = 0.5938) | | CC | 488 (62.97) | 530 (68.48) | 0.0197 | 1.000 | | 1.000 | | | CT | 257 (33.16) | 207 (26.74) | | 1.35 (1.08–1.68) | 0.0079 | 1.37 (1.09–1.70) | 0.0057 | | TT | 30 (3.87) | 37 (4.78) | | 0.88 (0.54–1.45) | 0.6160 | 0.90 (0.55–0.48) | 0.6794 | | Dominant | 287 (37.03) | 244 (31.52) | 0.0223 | 1.28 (1.03–1.58) | 0.0225 | 1.30 (1.05–1.60) | 0.0161 | | Recessive | 745 (96.13) | 737 (95.22) | 0.0786 | 0.80 (0.49–1.31) | 0.3815 | 0.82 (0.50–1.34) | 0.4193 | | ABCC4/rs3742106 A > C (HWE = 0.8429) | | AA | 171 (22.06) | 191 (24.68) | 0.1618 | 1.000 | | 1.000 | | | AC | 389 (50.19) | 399 (51.55) | | 1.09 (0.85–1.40) | 0.5026 | 1.09 (0.85–1.40) | 0.4829 | | CC | 215 (27.74) | 184 (23.77) | | 1.30 (0.98–1.74) | 0.0672 | 1.32 (0.99–1.76) | 0.0547 | | Dominant | 604 (77.93) | 583 (75.32) | 0.2243 | 1.16 (0.91–1.46) | 0.2250 | 1.17 (0.92–1.48) | 0.2032 | | Recessive | 560 (72.25) | 590 (76.23) | 0.0740 | 1.23 (0.98–1.55) | 0.0747 | 1.25 (0.99–1.57) | 0.0608 | | ABCC4/rs9561778 G > T (HWE = 0.3799) | | GG | 381 (49.16) | 410 (52.97) | 0.2779 | 1.000 | | 1.000 | | | GT | 332 (42.84) | 312 (40.31) | | 1.14 (0.93–1.41) | 0.2023 | 1.14 (0.93–1.41) | 0.2147 | | TT | 62 (8) | 52 (6.72) | | 1.28 (0.86–1.90) | 0.2160 | 1.25 (0.84–1.86) | 0.2625 | | Dominant | 394 (50.84) | 364 (47.03) | 0.1336 | 1.16 (0.95–1.42) | 0.1339 | 1.16 (0.95–1.41) | 0.1519 | | Recessive | 713 (92) | 722 (93.28) | 0.3338 | 1.21 (0.82–1.77) | 0.3358 | 1.18 (0.80–1.73) | 0.3950 | | ABCC4/rs1751034 C > T (HWE = 0.6842) | | CC | 36 (4.65) | 34 (4.39) | 0.8256 | 1.000 | | 1.000 | | | CT | 271 (34.97) | 282 (36.43) | | 0.91 (0.55–1.49) | 0.7026 | 0.94 (0.57–1.56) | 0.8223 | | TT | 468 (60.39) | 458 (59.17) | | 0.96 (0.59–1.57) | 0.8860 | 1.01 (0.61–1.63) | 0.9932 | | Dominant | 739 (95.36) | 740 (95.6) | 0.8110 | 0.94 (0.58–1.52) | 0.8111 | 0.98 (0.60–1.59) | 0.9346 | | Recessive | 307 (39.62) | 316 (40.82) | 0.6262 | 1.05 (0.86–1.29) | 0.6261 | 1.05 (0.86–1.29) | 0.6104 | | ABCC4/rs3765534 C > T (HWE = 0.5252) | | CC | 701 (90.45) | 677 (87.47) | 0.1689 | 1.000 | | 1.000 | | | CT | 73 (9.42) | 96 (12.4) | | 0.73 (0.53–1.01) | 0.0604 | 0.74 (0.53–1.02) | 0.0666 | | TT | 1 (.13) | 1 (.13) | | 0.97 (0.06–15.47) | 0.9804 | 0.73 (0.04–12.14) | 0.8294 | | Dominant | 74 (9.55) | 97 (12.53) | 0.0606 | 0.74 (0.53–1.01) | 0.0617 | 0.74 (0.54–1.02) | 0.0650 | | Recessive | 774 (99.87) | 773 (99.87) | 0.9993 | 1.00 (0.06–16.02) | 1.0000 | 0.75 (0.04–12.43) | 0.8421 | | ABCC4/rs868853 C > T (HWE = 0.2545) | | CC | 18 (2.32) | 18 (2.33) | 0.0256 | 1.000 | | 1.000 | | | CT | 228 (29.42) | 181 (23.39) | | 1.26 (0.64–2.49) | 0.5070 | 1.28 (0.65–2.54) | 0.4749 | | TT | 529 (68.26) | 575 (74.29) | | 0.92 (0.47–1.79) | 0.8056 | 0.92 (0.48–1.80) | 0.8190 | | Dominant | 757 (97.68) | 756 (97.68) | 0.9969 | 1.00 (0.52–1.94) | 0.9969 | 1.01 (0.52–1.96) | 0.9764 | | Recessive | 246 (31.74) | 199 (25.72) | 0.0087 | 0.74 (0.59–0.93) | 0.0088 | 0.74 (0.59–0.92) | 0.0067 | | Combined effect of risk genotypes | | 0–4 | 691 (89.16) | 722 (93.28) | | 1.000 | | 1.000 | | | 5-6 | 84 (10.84) | 52 (6.72) | 0.0040 | 1.63 (1.07–2.47) | 0.0217 | 1.63 (1.07–2.47) | 0.0229 |
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aχ2 test for genotype distributions between Kawasaki disease patients and controls; badjusted for age and gender.
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