Research Article
Diagnosis and Prognosis of Sepsis Based on Use of Cytokines, Chemokines, and Growth Factors
Table 4
Receiver operating characteristic curve analysis of eight chemokines and nine growth factors for diagnosis of sepsis.
| | Biomarkers | AUC | Cut-off | Sensitivity | (95% CI) | Specificity | (95% CI) | PPV | (95% CI) | NPV | (95% CI) | Accuracy | (95% CI) |
| | Chemokines | | | | | | | | | | | | | | CCL2 (MCP-1) | 0.840 | 105.5 | 67.5 | (64.5-70.4) | 93.0 | (91.5-94.5) | 0.90 | (82.3-97.6) | 75.4 | (65.9-85.1) | 80.7 | (74.1-87.3) | | CCL3 (MIP-1α) | 0.530 | 9.8 | 52.5 | (49.4-55.6) | 56.3 | (53.2-59.3) | 54.5 | (41.8-67.3) | 54.2 | (41.8-67.2) | 75.4 | (45.9-62.8) | | CCL4 (MIP-1β) | 0.653 | 411.8 | 47.5 | (44.3-50.5) | 87.5 | (85.5-89.5) | 79.2 | (68.8-89.5) | 62.5 | (51.7-73.2) | 67.5 | (59.9-75.4) | | CCL5 (RANTES) | 0.887 | 179.6 | 90.1 | (89.2-92.7) | 76.3 | (64.3-70.2) | 73.3 | (62.0-84.6) | 88.3 | (81.2-95.4) | 79.1 | (72.2-85.9) | | CCL11 (eotaxin) | 0.508 | 49.6 | 22.5 | (19.9-25.1) | 93.7 | (92.1-95.2) | 78.1 | (67.5-88.6) | 54.7 | (43.6-65.7) | 58.1 | (49.8-66.4) | | CXCL1 (GRO-α) | 0.759 | 1.0 | 55.0 | (51.9-58.1) | 96.3 | (95.1-97.4) | 93.6 | (87.4-99.8) | 68.1 | (57.8-78.5) | 75.6 | (68.4-82.8) | | CXCL10 (IP-10) | 0.851 | 46.5 | 71.3 | (68.4-74.1) | 92.5 | (90.8-94.1) | 90.4 | (82.9-97.8) | 76.3 | (66.8-85.8) | 81.9 | (75.4-88.4) | | CXCL12 (SDF-1) | 0.766 | 895.6 | 60.1 | (57.1-63.1) | 90.1 | (88.2-91.9) | 85.9 | (76.9-94.7) | 69.3 | (59.0-79.5) | 75.1 | (67.8-82.3) | | Growth factors | | | | | | | | | | | | | | BDNF | 0.690 | 393.3 | 57.5 | (54.4-60.5) | 82.5 | (80.1-84.8) | 76.6 | (65.8-87.4) | 66.0 | (55.4-76.5) | 70.0 | (62.2-77.7) | | EGF | 0.663 | 20.4 | 58.8 | (55.7-61.8) | 77.5 | (74.9-80.8) | 72.3 | (60.9-83.7) | 65.3 | (54.7-75.8) | 68.2 | (60.3-76.0) | | FGF-2 | 0.601 | 1.0 | 21.5 | (18.9-24.0) | 98.8 | (98.1-99.4) | 94.7 | (89.1-100) | 55.7 | (44.7-66.7) | 60.2 | (51.9-68.4) | | HGF | 0.899 | 341.2 | 76.3 | (73.6-78.9) | 92.5 | (90.8-94.1) | 91.1 | (83.7-98.3) | 79.6 | (70.1-88.5) | 84.4 | (78.2-90.5) | | NGF | 0.636 | 21.9 | 40.1 | (37.1-43.1) | 86.3 | (84.2-88.4) | 74.5 | (63.4-85.6) | 59.1 | (48.1-69.9) | 63.2 | (55.1-71.3) | | PDGF-BB | 0.677 | 279.6 | 38.8 | (35.7-41.8) | 90.1 | (88.2-91.5) | 79.6 | (69.4-89.9) | 59.5 | (48.6-70.4) | 64.4 | (56.3-72.5) | | PLGF-1 | 0.626 | 87.2 | 81.3 | (78.8-83.7) | 41.3 | (38.2-44.3) | 58.1 | (45.4-70.6) | 68.8 | (58.6-79.1) | 61.3 | (53.1-69.5) | | VEGF-A | 0.790 | 313.5 | 67.5 | (64.5-70.4) | 80.1 | (77.6-82.5) | 77.2 | (66.5-87.9) | 71.1 | (61.1-81.1) | 73.8 | (66.8-81.2) | | VEGF-D (FIGF) | 0.772 | 13.8 | 63.5 | (60.5-66.4) | 83.8 | (81.5-88.1) | 79.6 | (69.4-89.9) | 69.6 | (59.4-79.8) | 73.7 | (66.2-81.1) |
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AUC: area under receiver operating characteristic curve; PPV: positive predictive value; NPV: negative predictive value: CI; confidence intervals; CCL: CC motif chemokine ligand; CXCL: CXC motif ligand; BDNF: brain-derived neurotrophic factor; EGF: epidermal growth factor; FGF: fibroblast growth factor; GM-CSF: granulocyte macrophage colony stimulating factor; HGF: hepatocyte growth factor; NGF: nerve growth factor; PDGF: platelet-derived growth factor; PLGF: placental growth factor; SCF: stem cell factor; VEGF: vascular endothelial growth factor.
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