ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population

Table 10

Association of ABCB1 polymorphisms and drug resistance in male and female epileptic subgroups.

Male		Drug-resistant patients ()		Drug-responsive patients ()		ORs	95% CI	value	^2
			%		%
ABCB1 C1236T genotypes	TT vs. CC+CT	16	57.143	3	10.714	11.111	2.707-45.613	0.001	13.460
	TT vs. CC	16	84.211	3	25	16.000	2.654-96.472	0.003	10.870
	TT vs. CT	16	64	3	15.789	9.482	2.160-41.612	0.003	10.230
ABCB1 G2677T genotypes	TT vs. GG+GT	15	53.571	4	14.286	6.923	1.900-25.228	0.003	9.640
ABCB1 C3435T genotypes	TT vs. CC+CT	18	64.286	4	14.286	10.800	2.912-40.057	≤0.001	14.670
	TT vs. CC	18	78.261	4	22.222	12.600	2.843-55.841	0.001	12.750
ABCB1 C1236T alleles	T vs. C	41	73.214	22	39.286	4.224	1.901-9.386	≤0.001	13.100
ABCB1 C3435T alleles	T vs. C	41	73.214	18	32.143	5.770	2.554-13.037	≤0.001	18.950
ABCB1 G2677T-C3435T	TT	7	25	0	0	19.884	1.076-367.565	0.045	8
Female		Drug-resistant patients ()		Drug-responsive patients ()		ORs	95% CI	value	^2
			%		%
ABCB1 G2677T genotypes	TT vs. GT	12	75	2	9.524	28.500	4.504-180.326	≤0.001	16.550
ABCB1 C3435T genotypes	TT vs. CT	12	75	2	16.667	15.000	2.258-99.643	0.005	9.330

Values ( and %). ORs: odds ratio; 95% CI: confidence interval; significant value ≤ 0.05; ²: chi-square.