Circulating Levels of miR-574-5p Are Associated with Neurological Outcome after Cardiac Arrest in Women: A Target Temperature Management (TTM) Trial Substudy

Table 1

Demographic and clinical features of the 590 patients included in the present substudy.

	All patients; ()	Good outcome; ()	Poor outcome; ()	value; (Good vs. poor)
Age (years)	65 (20-94)	61 (20-90)	68 (35-94)	<0.001
Comorbidities
Hypertension	240 (41%)	102 (34%)	138 (47%)	0.001
Diabetes mellitus	86 (15%)	34 (11%)	52 (18%)	0.034
Known ischemic heart disease	163 (28%)	67 (22%)	96 (33%)	0.005
Previous MI	118 (20%)	48 (16%)	70 (24%)	0.020
Heart Failure	36 (6%)	9 (3%)	27 (9%)	0.003
COPD	55 (9%)	18 (6%)	37 (13%)	0.008
Renal failure	5 (1%)	1 (0%)	4 (1%)	0.353
Previous cerebral stroke	50 (8%)	19 (6%)	31 (11%)	0.084
Alcohol abuse	11 (2%)	4 (1%)	7 (2%)	0.513
First monitored rhythm				<0.001
VF or nonperfusing VT	467 (79%)	276 (92%)	191 (66%)
Asystole or PEA	104 (18%)	16 (5%)	88 (30%)
ROSC after bystander defibrillation	7 (1%)	5 (2%)	2 (1%)
Unknown	12 (2%)	2 (1%)	10 (3%)
Witnessed arrest	529 (90%)	276 (92%)	253 (87%)	0.045
Bystander CPR	433 (73%)	241 (81%)	192 (66%)	<0.001
Time from CA to ROSC (min)	25 (0-170)	20 (0-160)	30 (0-170)	<0.001
Initial serum lactate (mmol/l)	6.1 (0.5-25)	5.2 (0.5-20)	6.7 (0.5-25)	<0.001
Shock on admission	76 (13%)	27 (9%)	49 (17%)	0.007

Continuous variables are indicated as the median (range), and categorical variables are indicated as the number (frequency). CA: cardiac arrest; COPD: chronic obstructive pulmonary disease; CPR: cardiopulmonary resuscitation; MI: myocardial infarction; PEA: pulseless electric activity; ROSC: return of spontaneously circulation; VF: ventricular fibrillation; VT: ventricular tachycardia. Good outcome is CPC 1 or 2. Poor outcome is CPC 3, 4, or 5. Missing data: heart failure status for 2 patients, ischemic heart disease status for 1 patient, hypertension status for 1 patient, previous cerebral stroke status for 1 patient, diabetes mellitus status for 3 patients, alcohol abuse status for 1 patient, and lactate levels for 36 patients. values < 0.05 were considered statistically significant and are in bold.