PTPN22 Gene Polymorphisms Are Associated with Susceptibility to Large Artery Atherosclerotic Stroke and Microembolic Signals
Table 2
Genotype and allelic frequencies of PTPN22 SNPs in LAAS and control subjects.
SNP site
LAAS group (%)
Control group (%)
Univariate analysis OR (95% CI)a
value
Multivariate analysis adjusted OR (95% CI)b
value
rs2476599
Genotype
GG
323 (88.7%)
331 (89.7%)
1.000 (reference)
-
1.000 (reference)
-
GA
38 (10.4%)
37 (10.0%)
1.052 (0.653-1.697)
0.834
0.993 (0.591-1.669)
0.978
AA
3 (0.8%)
1 (0.3%)
3.074 (0.318-29.709)
0.603
5.057 (0.435-58.812)
0.195
GA+AA
41 (11.3%)
38 (10.3%)
1.106 (0.693-1.764)
0.673
1.069 (0.643-1.778)
0.797
Allele
G
684 (94.0%)
699 (94.7%)
1.000 (reference)
-
1.000 (reference)
-
A
44 (6.0%)
39 (5.3%)
1.153 (0.740-1.797)
0.529
1.145 (0.706-1.855)
0.584
rs1217414
Genotype
CC
302 (83.0%)
318 (86.2%)
1.000 (reference)
-
1.000 (reference)
-
CT
57 (15.7%)
47 (12.7%)
1.277 (0.842-1.938)
0.250
1.233 (0.786-1.935)
0.362
TT
5 (1.4%)
4 (1.1%)
1.316 (0.350-4.948)
0.943
1.452 (0.340-6.199)
0.614
CT+TT
62 (17.0%)
51 (13.8%)
1.280 (0.856-1.915)
0.229
1.249 (0.808-1.931)
0.317
Allele
C
661 (90.8%)
683 (92.5%)
1.000 (reference)
-
1.000 (reference)
-
T
67 (9.2%)
55 (7.5%)
1.259 (0.867-1.827)
0.225
1.242 (0.830-1.859)
0.292
rs2488457
Genotype
CC
125 (34.3%)
168 (45.5%)
1.000 (reference)
-
1.000 (reference)
-
CG
167 (45.9%)
161 (43.6%)
1.394 (1.015-1.914)
0.040
1.244 (0.881-1.757)
0.215
GG
72 (19.8%)
40 (10.8%)
2.419 (1.542.-3.796)
<0.001
2.275 (1.395-3.709)
0.001
CG+GG
239 (65.7%)
201 (54.5%)
1.598 (1.186-2.153)
0.002
1.444 (1.044-1.997)
0.027
Allele
C
417 (57.3%)
497 (67.3%)
1.000 (reference)
-
1.000 (reference)
-
G
311 (42.7%)
241 (32.7%)
1.538 (1.243-1.903)
<0.001
1.456 (1.156-1.833)
0.001
aUnivariate analysis; bmultivariate analysis (covariates: sex, age, history of smoking and drinking, hypertension, diabetes, dyslipidemia, and family history of ischemic stroke events).
