Decreased Expression of Urinary Mammalian Target of Rapamycin mRNA Is Related to Chronic Renal Fibrosis in IgAN

Table 1

Clinical profile of patients with IgA nephropathy and healthy controls at the time of the kidney biopsy.

	IgAN ()	Control ()	value
Age (years)	^a	^a	0.097^c
Gender (male/female)	86/68	37/24	0.157^d
Proteinuria (g/day)	^a	n.d.	—
Scr (mmol/l)	^a	^a	<0.001^c
BUN (mmol/l)	^a	^a	<0.001^c
Cystatin C (mg/l)	^a	^a	<0.001^c
eGFR (ml/min per 1.73 m^2)	^a	^a	<0.001^c
SBP (mmHg)	^a	^a	<0.001^c
DBP (mmHg)	^a	^a	0.026^c
Relative mTOR expression	0.412 (0.158-0.597)^b	1.147 (0.217-1.380)^b	<0.001^e
Usage of ACEI/ARB	96	n.d.	—
Usage of diuretic	83	n.d.	—
Oxford histological classification (number)
M score (0/1)	0/154	n.d.	—
E score (0/1)	80/74	n.d.	—
S score (0/1)	61/93	n.d.	—
T score (0/1/2)	62/65/27	n.d.	—
C score (0/1/2)	145/7/2	n.d.	—

^aData are presented as means (±SD). ^bData are presented as the median (min, max). ^cStudent’s -test. ^d tests. ^eMann–Whitney test. Abbreviations: Scr: serum creatinine; BUN: blood urea nitrogen; eGFR: estimated glomerular filtration rate; SBP: systolic blood pressure; DBP: diastolic blood pressure; M: mesangial hypercellularity; E: endocapillary hypercellularity; S: segmental glomerulosclerosis; T: tubular atrophy/interstitial fibrosis; n.d.: not determined.