Response to: Comment on “Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients”

Table 1

Test of substitution saturation by Xia’s method implemented in DAMBE [9, 10] on NS5A genotype 1a dataset used to analyse evolutionary relationships.

sequences	Iss	Symmetrical topology		Asymmetrical topology
		Iss.cSym		Iss.cAsym
4	0.124	0.825	0.0000	0.793	0.0000
8	0.129	0.795	0.0000	0.691	0.0000
16	0.137	0.778	0.0000	0.585	0.0000
32	0.144	0.757	0.0000	0.458	0.0000

I_ss: index of substitution saturation; I_ss.c: critical index of substitution saturation; : value for two-tailed tests.