Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure
Table 6
Sensitivity, specificity, and positive and negative predictive values.
Test variables
Sensitivity (95% CI)
Specificity (95% CI)
Positive predictive value (PPV) (95% CI)
Negative predictive value (NPV) (95% CI)
D20-pPWV
0.363 (0.123-0.683)
0.666 (0.509-0.795)
0.21 (0.069-0.46)
0.81 (0.642-0.914)
D20-EAA
0.333 (0.143-0.588)
0.657 (0.485-0.798)
0.315 (0.135-0.565)
0.675 (0.501-0.814)
LDL160-pPWV
0.055 (0.002-0.293)
0.605 (0.434-0.755)
0.062 (0.003-0.322)
0.575 (0.41-0.725)
LDL160-EAA
0.166 (0.04-0.422)
0.631 (0.459-0.777)
0.176 (0.046-0.441)
0.615 (0.446-0.761)
oxLDL-pPWV
0.25 (0.044-0.644)
0.843 (0.664-0.941)
0.285 (0.051-0.697)
0.818 (0.639-0.923)
oxLDL-EAA
0.153 (0.027-0.463)
0.814 (0.612-0.929)
0.285 (0.051-0.697)
0.666 (0.481-0.814)
CRP100-pPWV
0.833 (0.508-0.97)
0.272 (0.154-0.43)
0.238 (0.125-0.398)
0.857 (0.561-0.974)
CRP100-EAA
0.944 (0.706-0.997)
0.315 (0.18-0.487)
0.395 (0.253-0.555)
0.923 (0.62-0.995)
CRP300-pPWV
0.75 (0.428-0.933)
0.545 (0.389-0.693)
0.31 (0.159-0.509)
0.888 (0.697-0.97)
CRP300-EAA
0777 (0.519-0.926)
0.605 (0.434-0.755)
0.482 (0.298-0.671)
0.851 (0.653-0.951)
pPWV=pathological pulse wave velocity (increased for age); EAA=early arterial aging; oxLDL=oxidized LDL; LDL160=LDL > 160 mg/dl; CRP100=high-sensitivity C-reactive protein exceeding 0.100 mg/dl; CRP300=high-sensitivity C-reactive protein > 0.300 mg/dl; D20=vitamin D < 20 microg/l. The highest values for sensitivity, specificity, and NPV are in bold.
