Research Article

Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by 1H-NMR Spectrometry

Table 1

Changes in relative levels of metabolites in the serum samples from CRC patients, colorectal polyp patients, and healthy controls.

Metabolites (1H)Colorectal polyp vs. controlCRC vs. controlCRC vs. colorectal polyp
VIPChange/fold changeVIPChange/fold changeVIPChange/fold change

Lipid0.83-0.89 (bra)2.510.41/1.072.150.33/1.192.240.36/1.15
Leucine0.96 (t), 1.70 (m), 3.73 (m)1.30.52/1.081.160.45/1.232.040.45/1.16
Isoleucine9.92 (t), 1.02 (d), 3.73 (m)—/1.011.340.53/1.28—/1.01
Valine9.78 (d), 1.05 (d), 3.61 (d)1.920.54/1.093.770.50/1.173.030.35/1.12
3-Hydroxybutyrate1.20 (d), 2.28 (q), 2.40 (q), 4.15 (m)—/1.011.290.47/1.59—/1.08
Lactate1.33 (d), 4.12 (q)9.520.63/1.514.60.67/1.48—/1.06
Alanine1.48 (d), 3.78 (q)1.130.56/1.121.650.48/1.172.190.36/1.18
Acetate1.92 (s)1.460.57/1.211.250.54/1.18—/1.02
Glutamate2.08 (m), 2.34 (m)3.190.86/1.411.950.72/1.201.510.38/1.18
Glutamine2.13 (m), 2.45 (m)5.190.82/1.192.740.67/1.181.060.39/1.19
Succinate2.37 (s)2.570.63/1.121.840.57/1.23—/1.13
Citrate2.54 (d), 2.66 (d)—/1.012.920.61/1.212.790.54/1.17
Aspartate2.87 (m), 2.94 (m)1.490.74/1.401.510.76/1.62—/1.09
Choline3.20 (s)2.310.54/1.232.10.48/1.20—/1.02
Proline3.36 (m)—/1.034.030.65/1.203.410.44/1.26
Glycine3.57 (s)2.620.48/1.192.210.52/1.46—/1.04
Glucose3.24 (q), 3.48 (t), 3.90 (q), 3.54 (t), 3.71 (t), 3.83 (t)2.490.52/1.251.870.67/1.533.460.47/1.31
Serine3.84 (m), 3.96 (m)1.570.68/1.321.190.59/1.181.680.60/1.23
Tyrosine6.90 (d), 7.20 (d)—/1.011.010.52/1.191.120.54/1.22
NAc2.03 (s)1.090.62/1.27—/1.012.930.74/1.21
PUFA2.76-2.83 (bra)1.10.41/1.18—/1.041.460.43/1.37
Glycerol3.61 (m), 3.65 (m)1.740.61/1.32—/1.07—/1.05
Lysine1.45 (m), 1.71 (m), 1.89 (m), 3.02 (t), 3.75 (t)—/1.02—/1.031.040.49/1.26

s: single; d: doublet; dd: doublet of doublet; t: triplet; q: quartet; m: multiplet; bra: broad peak; ↑: increase; ↓: decrease; —: no significant change. ; .