Investigation of Key Genes and Pathways in Inhibition of Oxycodone on Vincristine-Induced Microglia Activation by Using Bioinformatics Analysis

Table 1

31 candidate prioritization differentially expressed genes from the ToppGene.

Rank	Gene name	Gene symbol	Interactant count	Score	Expression
1	Hemoglobin subunit beta	HBB	63	9.22-02	0.9249
2	Platelet factor 4	PF4	11	9.08-02	2.1651
3	Hemoglobin subunit alpha 2	HBA2	53	7.10-02	0.5341
4	Cystatin E/M	CST6	38	6.20-02	-0.6299
5	Squamous cell carcinoma antigen recognized by T cell 1	SART1	119	5.18-02	-0.9107
6	Insulin-like growth factor 2	IGF2	24	3.87-02	0.6439
7	Nephroblastoma overexpressed	NOV	18	3.71-02	0.8820
8	Kruppel-like factor 5	KLF5	54	3.58-02	0.5621
9	Interferon regulatory factor 7	IRF7	48	3.26-02	-0.5762
10	Mitochondrial ribosomal protein L11	MRPL11	65	3.22-02	-0.8362
11	Phospholipase A2 group IIA	PLA2G2A	29	2.89-02	1.3113
12	Solute carrier family 47 member 1	SLC47A1	27	2.83-02	0.7889
13	Myxovirus (influenza virus) resistance	MX1	43	2.75-02	-0.7250
14	SCY1-like pseudokinase 1	SCYL1	32	2.19-02	-1.0549
15	C-X-C motif chemokine ligand 10	CXCL10	10	1.82-02	0.9672
16	C-X-C motif chemokine ligand 9	CXCL9	9	1.42-02	0.8880
17	Tektin 2	TEKT2	19	1.34-02	0.5100
18	Secreted frizzled-related protein 2	SFRP2	20	1.25-02	0.7842
19	Sterol-C5-desaturase	SC5D	12	1.14-02	-0.5514
20	Hemogen	HEMGN	17	1.07-02	0.564234
21	Ring finger protein 113A2	RNF113A	20	9.74-03	-1.7287
22	Guanine nucleotide binding protein (G protein), gamma 11	GNG11	11	9.36-03	0.7967
23	Troponin T2, cardiac type	TNNT2	11	7.86-03	0.5085
24	Corticotropin-releasing hormone	CRH	5	5.88-03	-0.8934
25	Gap junction protein, beta 6	GJB6	6	4.49-03	0.5675
26	Alpha hemoglobin-stabilizing protein	AHSP	7	3.88-03	1.1388
27	Fibromodulin	FMOD	7	3.14-03	0.5468
28	Arachidonate 15-lipoxygenase	ALOX15	4	2.46-03	3.8408
29	Peroxisomal membrane protein 4	PXMP4	1	9.57-04	-1.2075
30	Cartilage intermediate layer protein	CILP	2	7.60-04	0.6077
31	Rh blood group, D antigen	RHD	1	2.97-04	0.5245