Research Article
NK Cells as Possible Prognostic Factor in Childhood Acute Lymphoblastic Leukemia
Table 1
Characteristics at initial diagnosis of group I (NK+) and group II (NK-).
| Variables | Overall () | Group | value | Group I (NK+) () median (25-75Q) N (%) | Group II (NK-) () median (25-75Q) N (%) |
| BCP ALL/T ALL Chi-squared test p 0.16 | 75/9 (89.3/10.7%) | 67/7 (90.5/9.5%) | 8/2 (80/20%) | | Age (yrs) median (range) | 5 (3–9) | 5 (3–10) | 5 (4–8) | 0.91 | Gender (M/F) | 49/35 (58/42%) | 42/32 (56.8/43.2%) | 7/3 (70/30%) | 0.02 | Ph(+)/Ph(-) | 5/79 (6/94%) | 4/71 (5/95%) | 1/8 (11/89%) | 0.95 | Protocol ALLIC 2002/2009 | 47/37 (56/44%) | 40/34 (54/46%) | 7/3 (70/30%) | 0.29 | Risk groups SRG/IRG/HRG | 24/46/14 (28.6/54.8/16.6%) | 22/40/12 (29.8/54/16.2%) | 2/6/2 (20/60/20%) | 0.84 | Day 8 PGR/PPR | 78/6 (92.8/7.2%) | 71/3 (96/4%) | 7/3 (70/30%) | 0.01 | Day 15 bone marrow M1/M2/M3 | 63/13/8 (75/15.5/9.5%) | 60/7/7 (81/9.5/9.5%) | 3/6/1 (30/60/10%) | 0.03 | Day 15 () MRD <0.01/0.01-≤10.0/>10.0 | 18/11/8 (48.6/29.8/21.6%) | 16/10/8 (47.1/29.4/23.5%) | 2/1/0 (66.7/33.3/0%) | 0.03 | Day 33 bone marrow | 80/4 (95/5%) | 70/4 (94.6/5.4%) | 9/1 (90/10%) | 0.81 |
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Bone marrow M1 < 5% lymphoblasts; bone marrow M2 ≥ 5–<25% lymphoblasts; bone marrow M3 ≥ 25% lymphoblasts. Day 15: minimal residual disease was made in 37 pts. HRG: high-risk group. IRG: intermediate-risk group. SRG: standard-risk group. MRD: minimal residual disease. Ph (+): Philadelphia chromosome positive. Ph (-): Philadelphia chromosome negative. PGR: prednisone good response (blast cells in peripheral blood < 1000.0/μl). PPR: prednisone poor response (blast cells in peripheral blood ≥ 1000.0/μl).
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