Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries

Table 4

Diagnostic values of GP73, ALT, and AST for liver inflammatory activity ().

Parameters	AUC	95% CI	Cutoff value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	value
(Cohort A)
GP73	0.717	(0.620, 0.800)	103.5	43.64	92.00	85.7	59.7	<0.0001
ALT	0.685	(0.587, 0.772)	40	69.09	64.00	67.9	65.3	0.0005
AST	0.782	(0.691, 0.857)	40	69.09	74.00	74.5	68.5	<0.0001
(Cohort B)
GP73	0.794	(0.710, 0.862)	64.43	82.52	64.71	93.4	37.9	<0.0001
ALT	0.777	(0.692, 0.848)	40	58.25	82.35	95.2	24.6	<0.0001
AST	0.769	(0.683, 0.841)	40	44.66	88.24	95.8	20.8	<0.0001

GP73: Golgi protein 73; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AUC: area under the curve; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value.