What Is the Biological Function of Uric Acid? An Antioxidant for Neural Protection or a Biomarker for Cell Death

Table 1

Top 20 pathways with significance could be associated with the level of uric acid in different organs.

ID	Description	Significant	Annotated	value	value	Positive num.	Negative num.
ko03010	Ribosome	184/1937	288/7604	1.26E-44	3.37E-42	172	12
ko04141	Protein processing in the endoplasmic reticulum	89/1937	172/7604	8.09E-14	1.09E-11	62	27
ko00240	Pyrimidine metabolism	50/1937	106/7604	9.93E-07	8.89E-05	36	14
ko04975	Fat digestion and absorption	24/1937	39/7604	1.99E-06	0.000134	21	3
ko00520	Amino sugar and nucleotide sugar metabolism	27/1937	49/7604	8.96E-06	0.000481	19	8
ko05110	Vibrio cholerae infection	28/1937	52/7604	1.11E-05	0.000494	14	14
ko00230	Purine metabolism	68/1937	170/7604	1.88E-05	0.000721	38	30
ko00480	Glutathione metabolism	28/1937	54/7604	2.80E-05	0.000941	21	7
ko00983	Drug metabolism (other enzymes)	22/1937	39/7604	3.73E-05	0.001011	19	3
ko03460	Fanconi anemia pathway	27/1937	52/7604	3.77E-05	0.001011	18	9
ko03008	Ribosome biogenesis in eukaryotes	37/1937	81/7604	5.99E-05	0.001462	25	12
ko00620	Pyruvate metabolism	23/1937	43/7604	7.72E-05	0.001727	10	13
ko00330	Arginine and proline metabolism	28/1937	59/7604	0.000209	0.004278	17	11
ko00500	Starch and sucrose metabolism	21/1937	40/7604	0.000223	0.004278	12	9
ko03030	DNA replication	20/1937	38/7604	0.000301	0.00538	16	4
ko00900	Terpenoid backbone biosynthesis	14/1937	23/7604	0.000342	0.005742	10	4
ko00561	Glycerolipid metabolism	26/1937	56/7604	0.000534	0.008435	19	7
ko04972	Pancreatic secretion	40/1937	98/7604	0.000587	0.008748	33	7
ko04113	Meiosis (yeast)	26/1937	59/7604	0.001403	0.019819	19	7
ko04111	Cell cycle (yeast)	29/1937	70/7604	0.002443	0.032791	24	5
ko00970	Aminoacyl-tRNA biosynthesis	21/1937	47/7604	0.003207	0.03985	12	9
ko00510	N-Glycan biosynthesis	22/1937	50/7604	0.003266	0.03985	19	3
ko02020	Two-component system	10/1937	17/7604	0.003564	0.041593	6	4
ko04110	Cell cycle	45/1937	123/7604	0.003905	0.043679	42	3
ko04210	Apoptosis	33/1937	85/7604	0.004440	0.045337	21	12
ko03440	Homologous recombination	14/1937	28/7604	0.004476	0.045337	10	4
ko00100	Steroid biosynthesis	11/1937	20/7604	0.004560	0.045337	11	0
ko04910	Insulin signaling pathway	48/1937	134/7604	0.004738	0.045421	19	29
ko00564	Glycerophospholipid metabolism	35/1937	92/7604	0.005061	0.046841	23	12
ko03060	Protein export	12/1937	23/7604	0.005410	0.048403	8	4