Research Article
KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo
Figure 4
Inhibitory role of KIF5A silencing in vivo. (a) Xenograft assay. After 7 weeks of treatment, the tumor volume of KIF5A downregulation group was significantly smaller than in the control in subcutaneous and metastatic sites (). (b, c) Results suggested that KIF5A protein level was dramatically reduced by our recombinant AAV in the injected tumor xenografts in nude mice by western blot and IHC assays (). (d) The expression of proliferation markers Ki67 and PCNA in vivo measured by western blot. Knocking down KIF5A inhibited Ki67 and PCNA expression (). All results are performed of at least three independent experiments.
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