Research Article
Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease
Table 1
Characteristics in two patient groups with IDA (sideropenic anemia) and ACD (ESRD patients).
| | Characteristic | Sideropenic anemia () | ESRD patients () | |
| | Gender (females) (%) | 100 | 44 | <0.001 | | Age (years) | 42 (33-47) | 61 (46-66) | <0.001 | | Serum urea (mmol/L) | 4.00 (3.40-4.90) | 19.90 (17.02-23.22) | <0.001 | | Serum creatinine (μmol/L) | 65.00 (58.00-70.00) | 766.00 (592.25-913.25) | <0.001 | | eGFR (mL/min/1.73m2) | >60 | 6.00 (5.00-7.00) | — | | Hepcidin-25 (ng/mL) | 3.00 (2.74-3.05) | 53.98 (18.82-110.51) | <0.001 | | Hemoglobin (g/L) | 103.00 (97.30-111.70) | 104.95 (95.82-113.78) | 0.776 | | Serum iron (μmol/L) | 6.00 (3.90-9.90) | 11.9 (9.85-15.55) | <0.001 | | TIBC (μmol/L) | 69.50 (62.60-73.30) | 40.60 (35.18-47.52) | <0.001 | | Transferrin (g/L) | 3.18 (2.87-3.30) | 1.73 (1.56-1.91) | <0.001 | | TS (%) | 8.40 (5.30-14.60) | 29.80 (23.40-37.25) | <0.001 | | sTfR (mg/L) | 2.43 (1.94-3.51) | 1.25 (0.93-1.64) | <0.001 | | Ferritin (μg/L) | 8.00 (8.00-8.50) | 256.70 (81.35-593.15) | <0.001 | | CRP (mg/L) | 1.20 (0.50-3.00) | 2.70 (1.50-7.90) | <0.001 | | RBC (×1012/L) | 4.23 (4.09-4.54) | 3.41 (3.15-3.74) | <0.001 | | WBC (×109/L) | 6.75 (5.66-8.45) | 6.44 (5.55-7.80) | 0.586 | | MCV (fL) | 75.88 (71.01-78.00) | 93.88 (91.00-97.16) | <0.001 | | RDW (fL) | 17.05 (15.70-18.06) | 15.02 (13.99-16.35) | <0.001 |
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Continuous variables were presented as median (interquartile range); ESRD: end-stage renal disease; eGFR: estimated glomerular filtration rate; TIBC: total iron-binding capacity; TS: transferrin saturation; sTfR: soluble transferrin receptor; CRP: C-reactive protein; RBC: red blood cell count; WBC: white blood cell count; MCV: mean corpuscular volume; RDW: red cell distribution width.
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