Diet Alters Serum Metabolomic Profiling in the Mouse Model of Chronic Chagas Cardiomyopathy

Figure 5

Comparison of acylcarnitine profiling between T. cruzi-infected and uninfected mice fed on different diets at 150 DPI. (a) Heat map representing the serum levels of various acylcarnitines during chronic infection in mice fed on either a RD or a HFD compared to uninfected RD mice at 150 DPI. Each row represents data for a specific metabolite, and each column represents the RD-fed uninfected (RD), RD-fed infected (RDI), HFD-fed uninfected (HFD), or HFD-fed infected (HFDI) mouse group. Different colors correspond to the different intensity level of metabolites (red > the control RD group and green < the control RD group). Statistically significant differences were tested using Student’s -test, and the corrected values (-value) are presented next to the heat map. Red, yellow, and green rectangles indicate high, moderate, and low expressions, respectively. (b) The percentage changes in the levels of acylcarnitines in infected mice compared to the respective diet-fed (RD and HFD) uninfected mice represented by a bar graph (significant change).

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